Evidence map›Paper›PMID 40715358›Full record

Trial reportPediatric research2026

Home-based early intensive manual therapy in unilateral cerebral palsy under 2 years of age.

Rocío Palomo-Carrión, Elena Pinero-Pinto, Cristina Lirio-Romero, Helena Romay-Barrero, Asunción Ferri-Morales, Rita-Pilar Romero-Galisteo

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06191588 (Feasibility and Effectiveness of Home-base Early Intensive Therapy in Unilateral Cerebral Palsy), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06191588 nacompletednot on this map

Feasibility and Effectiveness of Home-base Early Intensive Therapy in Unilateral Cerebral Palsy (Ucp-HEIT) Under-2-years-old

TypeinterventionalSponsorUniversity of SevilleRan2023 to 2024Enrolled10ConditionsInfantile Hemiplegia, Constraint Induced Movement Therapy, Family, Bimanual Intensive TherapyArmsINFANT CIMT/BIT
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rocío Palomo-CarriónFaculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, UCLM, Toledo, Spain.ORCID http://orcid.org/0000-0003-4034-2585
Elena Pinero-PintoFaculty of Nursing, Physiotherapy and Podiatry, Department of Physiotherapy, University of Seville, Seville, Spain. epinero@us.es.ORCID http://orcid.org/0000-0001-9611-3939
Cristina Lirio-RomeroFaculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, UCLM, Toledo, Spain.
Helena Romay-BarreroFaculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, UCLM, Toledo, Spain.
Asunción Ferri-MoralesFaculty of Physiotherapy and Nursing, Department of Nursing, Physiotherapy and Occupational Therapy, University of Castilla-La Mancha, UCLM, Toledo, Spain.
Rita-Pilar Romero-GalisteoFaculty of Health Sciences, University of Málaga, Málaga, Spain.ORCID http://orcid.org/0000-0003-4669-0679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildren with unilateral cerebral palsy (UCP) learn not to use their affected upper limb, which is known as "developmental disregard". Consequently, early intensive training could improve hand function, increasing spontaneous use for the first 2 years of life, where there is a great window for brain changes due to neural plasticity.

objectiveTo study the effectiveness of home-based infant-intensive manual therapies in facilitating bimanual functional performance (BFP) compared to standard care in children with UCP aged 9-18 months.

methodsA randomized controlled trial with single-blinded outcome assessment was conducted. Children were randomized into four groups: modified Constraint-Induced Movement Therapy for infants (infant-mCIMT), Bimanual Intensive Therapy for infants (InfantBIT), Hybrid Therapy, combining mCIMT and BIT, for infants (Infant-hybrid) and conventional therapy for children (Infant-standard-Therapy, control group-CG). Each early intensive protocol lasted 50 h and was applied throughout a 10-week period. The main outcomes were BFP, functional goals and parental satisfaction expectations regarding intensive manual therapy. Three measurements were performed (at Week 0, Week 10 and 6 months after treatment).

resultsForty infants aged 12.38 months (chronological age) met the inclusion criteria. All groups except CG showed significant increases in BFP after infant intensive manual therapy and at 6 months compared with the baseline assessment (p < 0.01). The greatest increases in goal achievement and parent satisfaction occurred in the groups that had an mCIMT component.

conclusionsCompared with standard therapy, early intensive manual therapies, i.e., infant-mCIMT, infant-BIT and infant-Hybrid therapy, resulted in greater increases in BFP and were maintained at the 6-month follow-up. CLINICAL

trial registrationClinicalTrials.gov: NCT06191588. IMPACT: Home-based early intensive manual therapies increase bimanual functional performance to a greater extent than conventional therapy. Infant-Hybrid therapy may result in greater improvements in functional bimanual performance compared to Infant-mCIMT or Infant-BIT alone. Higher therapy intensity and family involvement, particularly in home-based programs, are key factors for improving hand function compared to lower-dose, clinic-based usual care.

Indexed as

Cerebral PalsyConstraint Induced Movement TherapyHome Care ServicesMusculoskeletal ManipulationsFemaleHumansInfantMaleSingle-Blind MethodTreatment Outcome

Identifiers

PMID40715358

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.