SynthesisPediatric research2026
Home phototherapy for neonatal hyperbilirubinemia: a mixed methods systematic review and meta-analysis.
Synthesis in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Efficacy and safety of home-based fiberoptic blanket versus hospital-based light-emitting diode phototherapy for neonatal jaundice: a retrospective cohort study from Thailand.Clinical and experimental pediatrics · 2026Article
- Assessing the cost-effectiveness of home phototherapy.Pediatric research · 2026Article
- Design and Photometric Optimization of a Low-Cost Phototherapy Bed for Neonatal Jaundice.Annals of biomedical engineering · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo promote home phototherapy adoption, clearer insights are needed on current evidence and the population most likely to benefit.
methodsSix online databases were searched until 20 January 2025. Studies were included that reported on (cost-)effectiveness, safety, and/or implementation barriers and facilitators of home phototherapy. Two reviewers independently extracted data and assessed bias using the Mixed Methods Appraisal Tool. Data were pooled via random-effects meta-analysis. Barriers and facilitators were analyzed using the Theoretical Domains Framework. GRADE was used to assess evidence quality.
resultsThirty-one studies were included, representing 5059 neonates, 869 healthcare professionals, and 478 parents. Risk of bias was moderate. Hospital (re)admission following home phototherapy was 3.5% (95% CI, 2.2-5.3%). No difference was found in treatment duration (mean difference = +4.9 h, 95% CI -8.0 to +17.9) and daily decline in bilirubin (mean difference = +5.7 μmol/L, 95% CI -2.6 to +13.9). No studies evaluated cost-effectiveness. Key facilitators included eligibility screening and parental education, while key barriers included bilirubin measurement, healthcare professionals' concerns about homecare consequences, and parental insecurity. Quality of evidence was rated low for all outcomes.
conclusionEvidence suggests home phototherapy can be an alternative to in-hospital treatment for hyperbilirubinemia in near-term neonates. Clinical recommendations are limited due to low-certainty evidence. IMPACT: Home phototherapy can be a safe and effective alternative to in-hospital treatment for low-risk neonates with hyperbilirubinemia. Strength of this recommendation is low. Our study is the first to systematically synthesize parent/caregiver and healthcare professional perspectives on home phototherapy using the Theoretical Domains Framework. Key facilitators included eligibility screening and parental education, while key barriers included concerns about home care consequences by healthcare professionals and parental insecurity. Addressing these barriers through improved support and accurate monitoring is recommended.
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