ArticleScientific reports2025
Association between vitamin D receptor FokI gene polymorphism and risk of type 2 diabetes mellitus in the Ethiopian population.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D receptor genes, including FokI gene polymorphisms, have been widely studied and shown to be associated with susceptibility to type 2 diabetes mellitus in various populations. The objective of this study was to determine the association between vitamin D receptor FokI gene polymorphisms and the risk of type 2 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. Seventy type 2 diabetes mellitus patients and 70 healthy controls participated in an age- and sex-matched hospital-based case-control study. We assessed demographic data to determine the related risk factors. Deoxyribonucleic acid was extracted from blood samples and subjected to polymerase chain reaction and agarose gel electrophoresis analysis to determine the FokI genotypes. Both the FokI ff genotype (odds ratio 3.16; 95% confidence level 1.25-7.75; P = 0.012) and f allele (odds ratio 2.21; 95% confidence level 1.35-3.62; P = 0.0015) were substantially more prevalent in patients than in controls, suggesting that they may be risk factors for the development of type 2 diabetes mellitus. The findings point to a potential link between FokI gene polymorphisms and the development of type 2 diabetes mellitus in the Ethiopian population under study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.