ArticleScientific reports2025
SARS-CoV-2 mRNA vaccines confer protection in diet-induced obese mice despite altered immune cell profiles in the lung.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- Females with Obesity Exhibit Greater Influenza Vaccine-induced Immunity and Protection than Males in a Mouse Model.bioRxiv : the preprint server for biology · 2025Article
- Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension, diabetes, and obesity are comorbidities that influence severe cases of COVID-19 and are associated with weak humoral immunity after vaccination. We hypothesized that the diet-induced obese (DIO) K18-hACE2 mouse model could be utilized to reveal sex and DIO- specific differences in responses to COVID-19 immunization. To test this hypothesis, we immunized male and female DIO mice with a COVID-19 mRNA vaccine. Female DIO mice after immunization showed higher neutralizing antibody levels that recognized both SARS-CoV-2 variant RBD than male DIO mice. After Omicron SARS-CoV-2 challenge, single cell RNA sequencing analysis of lung tissue suggested decreased naïve B cell populations in immunized DIO mice in addition to an increase in macrophages in vaccinated female DIO mice. Analysis of viral burden revealed that the DIO variable did not impact immunity in immunized mice. Overall, this study underscores the ability of COVID-19 mRNA vaccines to confer protection in the comorbid SARS-CoV-2 murine challenge model.
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Registered trials
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