ArticleScientific reports2025
Development of a time-resolved fluorescence-based lateral flow immunoassay for rapid and sensitive diagnosis of Middle East respiratory syndrome.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Recent Advances in Lateral Flow Immunoassay for Rapid Diagnosis of Viral Diseases.Transboundary and emerging diseases · 2026Review
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10 authors.
Funding
Abstract
Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by the MERS-coronavirus (MERS-CoV). Due to its high mortality and lack of a vaccine or treatment, MERS has remained on the WHO's priority list of diseases with the highest public health risk since 2012. Although rapid diagnosis is essential for interrupting transmission, initiating timely treatment, and maintaining public health systems, no rapid diagnostic method currently exists for MERS. In this study, a sensitive and specific lateral flow immunoassay (LFIA)-based rapid antigen diagnostic test for MERS was developed using time-resolved fluorescence (TRF) technology. Monoclonal antibodies specific for the MERS-CoV N protein were generated, and optimal pairs were selected through affinity measurement. A TRF-LFIA using Europium nanoparticles was then constructed based on these pairs. The TRF-LFIA showed a detection limit of 0.1 ng/ml MERS-CoV N protein and 5 × 10
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