ArticleScientific reports2025
Detection of neuroglobin in umbilical cord blood signals progress in perinatal medicine.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To assess whether Neuroglobin could play a functional role during perinatal period and birth, it was analyzed in 83 umbilical cord blood samples where its concentration ranged between 1.65 and 45.18 ng/mL, mean 18.49 ng/mL. Although resembling concentrations previously detected in many pathologic conditions in adults, none of newborns displayed altered Apgar score and were regularly discharged in healthy status. Surprisingly, 83.13% of babies had NGB concentrations higher than the putative 8.4 ng/mL value, recently hypothesized as a prognostic cut-off between good and bad recovery from cerebral ischemia in adults. Significant Pearson correlations were observed between NGB and Hb (r = 0.368, p = 0.001), and Htc (r = 0.372, p = 0.001) confirming its physiological role in oxygen-regulated metabolic information within the child-mother dyad. Besides the direct action in regulating blood flow and gas exchange, the first NGB discovery in cord blood is discussed in relation to new perspectives in perinatal medicine.
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