ArticleScientific reports2025
In vitro and in silico neuroprotective evaluation of new biotransformation metabolites of (-)-α-bisabolol.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biotransformation of (-)-α-bisabolol (1) was investigated by screening twenty-two fungal strains in an effort to produce new more polar and potentially bioactive metabolites. Three fungi were selected for scale-up biotransformation: Cordyceps sinensis, Alternaria alternata and Aspergillus flavus. Five metabolites were isolated: 10β,11-dihydroxy-α-bisabolol (2), Hamanasic acid A (3), 2,3-dihydro-α-bisabolol (4), 7-dehydroxy-10,11-epoxy-3-methylcarboxy-α-bisabolol (5) and 10β,11,15-trihydroxy-α-bisabolol (6), with metabolites 4, 5, and 6 being newly identified. Structural elucidation was performed using spectroscopic methods. α-bisabolol and its metabolites were evaluated for their cyclooxygenase (COX) and acetylcholinesterase (AChE) inhibitory activities, as well as neuroprotective effects against H
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