ArticleScientific reports2025
Clinical and molecular epidemiology of chikungunya outbreaks during 2019-2022 in India.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Global resurgence of Chikungunya virus: outbreak drivers and emerging solutions.Emerging microbes & infections · 2026Review
- Differentiated mosquito adaptive strategies underlie regional dominance of three ECSA sub-lineages in chikungunya virus.PLoS pathogens · 2026Article
- Resurgence of Chikungunya in Thailand.IJID regions · 2026Article
- Detection and genomic characterization of a travel-associated ECSA lineage chikungunya virus infection in Mexico.ASM case reports · 2026Article
- Genomic and Immunological Insights Into Chikungunya Virus Evolution During the 2018 and 2023-24 Outbreaks in Southern India.Journal of medical virology · 2026Article
- Development and validation of an interpretable machine learning model for early hospital-based differentiation of chikungunya and dengue fever using routine clinical data.BMC infectious diseases · 2026Observational
- Seroprevalence of chikungunya virus in Colombo, Sri Lanka before the 2025 outbreak and implications for population susceptibility.medRxiv : the preprint server for health sciences · 2026Article
- Chikungunya in 2025: Comprehensive Insights into Virology, Diagnostics, Vaccines, and Antiviral Therapies.Viruses · 2026Review
- Clinical epidemiology and viral genomics insights from a Chikungunya fever outbreak in South China, 2025.Frontiers in cellular and infection microbiology · 2026Article
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Abstract
Chikungunya fever (CHIKF) is endemic in India, with multiple outbreaks occurring across the country since its reemergence in 2005. Suspected CHIKF patients were recruited from four clinical sites during 2019-2022, with data collected on sociodemographic, clinical, and epidemiological aspects. Sera samples were screened for IgM, IgG antibodies and viral RNA along with their neutralizing capacity. Envelope genes of Chikungunya virus (CHIKV) isolated were sequenced and further analysed. A total of 1312 suspected patients were screened during the study period; 258 patients were laboratory-confirmed with CHIKV infection. Severe clinical manifestation was observed in the patients during the viremic phase of infection. The neutralization potential was found to be increasing proportionally with the onset of illness, coinciding with the rise of IgG antibodies. Three of the four clinical sites had reported CHIKF outbreaks at different time points during the study period, and a distinct pattern of clinical presentation was observed across the sites. Phylogenetic and network analyses of E1, E2 and E3 genes from 62 CHIKV isolates demonstrated their evolution within the country. This study provides preliminary evidence of spatial and temporal variation in the clinical presentation and molecular evolution of virus in CHIKF outbreaks across India.
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