Evidence map›Paper›PMID 40715150›Full record

ArticleNature communications2025

Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents.

Saymon Tejay, Maria Areli Lorenzana-Carrillo, Guocheng Huang, Seyed Amirhossein Tabatabaei Dakhili, Yuan -Yuan Zhao, Farah Eaton, Michelle Mendiola Pla, Dawn E Bowles, Adam Kinnaird, D Ian Paterson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Saymon TejayDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Maria Areli Lorenzana-CarrilloDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0003-3268-7436
Guocheng HuangCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
Seyed Amirhossein Tabatabaei DakhiliCardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-8104-5029
Yuan -Yuan ZhaoDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Farah EatonCardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada.
Michelle Mendiola PlaDepartment of Surgery, Duke University, Durham, NC, 27710, USA.ORCID http://orcid.org/0000-0001-9348-7708
Dawn E BowlesDepartment of Surgery, Duke University, Durham, NC, 27710, USA.
Adam KinnairdCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
D Ian PatersonUniversity of Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada.
Edith PituskinCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
John R UssherCardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0001-9574-5707
Evangelos D MichelakisDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0003-0787-7721
Gopinath SutendraDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada. sutendra@ualberta.ca.ORCID http://orcid.org/0000-0002-8181-1483

Funding

Canada Research Chairs (Chaires de recherche du Canada) CRCTIER2 2021-00025
6 · The paper itself

Abstract

It is well established tumour cells secrete signalling factors affecting distant normal tissues. What remains unresolved is whether these factors initiate a signalling cascade rendering terminally differentiated cardiomyocytes susceptible to apoptosis, a feature of chemotherapy-induced cardiotoxicity (CIC). Here we show in MANTICORE trial cancer patients, cumulative baseline plasma levels of the nucleoside inosine and its derivative hypoxanthine predict cardiotoxicity. We found the Zn

Indexed as

Antineoplastic AgentsCardiotoxicityDNA DamageMyocytes, CardiacNeoplasmsRNA-Binding ProteinsRNA Splicing FactorsAnimalsApoptosisFemaleHumansHypoxanthineInosineMaleSignal TransductionAntineoplastic AgentsHypoxanthineInosineRNA-Binding ProteinsRNA Splicing Factors

Identifiers

PMID40715150
PMCPMC12297588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.