Late-stage O-sulfation with a bioinspired sulfuryl donor.

Ye Zheng, Li Huang, Chunlan Song, Jiakun Li

Abstract read

In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ye ZhengState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.

Li HuangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.

Chunlan SongState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.

Jiakun LiState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China. jkli@hnu.edu.cn.ORCID http://orcid.org/0000-0002-7361-3372

Funding

Natural Science Foundation of Hunan Province (Hunan Provincial Natural Science Foundation) 2025JJ40012

6 · The paper itself

Abstract

O-sulfation is a widespread modification of both endogenous and exogenous biomolecules, where the primary objective is to identify effective sulfuryl donors. In nature, 3'-phosphoadenosine-5'-phosphosulfate (PAPS) and p-nitrophenyl sulfate (PNPS) are efficient sulfuryl donors. However, most chemical sulfuryl donors in O-sulfation, typically require harsh conditions and have not been demonstrated in complex molecules. Here we report a biomimetic O-sulfation method that is compatible with complex natural products and pharmaceutical scaffolds. Key to this approach is the use of tetrabutylammonium (

Identifiers

PMID40715113

DOI10.1038/s41467-025-62093-2

PMCPMC12297285

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.