Evidence map›Paper›PMID 40715079›Full record

ArticleNature communications2025

Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier.

Justin C Rudd, Jos P H Smits, Patrick T Kuwong, Rachel E Johnson, Louise M N Monga, Ivonne M J J van Vlijmen-Willems, Greer L Porter, Peter O Halloran, Kanika Sharma, Karina N Schmidt and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The human Flower isoform hFWE4 facilitates cornification in cutaneous squamous cell carcinoma.JID innovations : skin science from molecules to population health · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Justin C RuddDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA.
Jos P H SmitsDepartment of Dermatology, Radboud Research Institute for Medical Innovation, Nijmegen, The Netherlands.
Patrick T KuwongDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA.ORCID http://orcid.org/0009-0004-0906-0453
Rachel E JohnsonDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA.
Louise M N MongaDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA.
Ivonne M J J van Vlijmen-WillemsDepartment of Dermatology, Radboud Research Institute for Medical Innovation, Nijmegen, The Netherlands.
Greer L PorterDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA.
Peter O HalloranDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA.
Kanika SharmaMass Spectrometry and Proteomics Core Facility, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Karina N SchmidtDepartment of Dermatology, University of Washington, Seattle, Washington, USA.
Vikas KumarMass Spectrometry and Proteomics Core Facility, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Justin G MadsonMidwest Dermatology, Omaha, Nebraska, USA.ORCID http://orcid.org/0009-0006-6184-9018
Mrinal K SarkarDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0001-8505-4259
Ellen H van den BogaardDepartment of Dermatology, Radboud Research Institute for Medical Innovation, Nijmegen, The Netherlands.
James A GrunkemeyerDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-0080-0812
Sunny Y WongDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Cory L SimpsonDepartment of Dermatology, University of Washington, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-3933-6404
Laura A HansenDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA. LauraHansen@creighton.edu.

Funding

Exploring hair follicle-associated functions in normal and ichthyotic skinR01AR080654 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sunny Y Wong · 2022 to 2026
$2.0M
NIAMS NIH HHS R01 AR080654
6 · The paper itself

Abstract

Specialized secretory cells, including keratinocytes in the last viable layers of mammalian epidermis, utilize lysosome-related organelles (LROs) to exocytose distinct cargoes vital for tissue function. Here, we demonstrate that the Flower isoform, hFWE4, a putative Ca

Indexed as

Calcium ChannelsEpidermisAnimalsCalciumHumansKeratinocytesLysosomesMiceOrganellesCalciumCalcium Channels

Identifiers

PMID40715079
PMCPMC12297442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.