ArticleNature communications2025
Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The genetic signature of memory encoding along the human hippocampal axis.bioRxiv : the preprint server for biology · 2026Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
4 authors.
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Abstract
In humans, the hippocampus exhibits evident structural and connectivity differences along the longitudinal axis. Experiments in rodents and more recently in human subjects have stimulated several theories of functional longitudinal specialization. This question pertains directly to the management of neurosurgical patients, as nascent technologies permit more precise treatments that can selectively spare longitudinal regions. With this in mind, we investigated hippocampal longitudinal specialization in 32 human intracranial EEG subjects as they performed an associative recognition episodic memory task. Utilizing the behavioral contrasts available in this task, we characterize the neurophysiological features that distinguish the anterior versus posterior hippocampal activity during recollection and familiarity-based memory retrieval, as well as novelty processing. We use subspace representations to characterize longitudinal differences in the temporal dynamics of key computational processes ascribed to the hippocampus, namely pattern separation and pattern completion. We place our findings in the context of existing models, adding to sparse literature using direct brain recordings to explicate the functional differentiation along the hippocampal longitudinal axis in humans.
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