SynthesisWorld journal of surgery2025
Meta-Analysis to Determine Optimal Timing for Repair of Inguinal Hernia in Pre-Term Infants.
Synthesis in World journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analysis to Determine Optimal Timing for Repair of Inguinal Hernia in Pre-Term Infants.World journal of surgery · 2025Pooled it
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies have shown conflicting findings regarding the optimal time for the repair of inguinal hernia in preterm infants. Our review aims to comprehensively synthesize the available evidence and provide robust, up-to-date insights into the clinical outcomes of delayed versus early repair of inguinal hernia in these patients.
methodsA comprehensive search across PubMed, Cochrane Library, Clinicaltrials.gov, and Embase was conducted from inception until July 2024 to include RCTs and cohort studies comparing early versus delayed inguinal hernia repair. The odds ratios (ORs) were pooled along with corresponding 95% confidence intervals (CIs) for all clinical endpoints with the random effects model using RevMan 5.4.
resultsOur meta-analysis pooled 10 studies involving 4253 preterm infants. The early hernia repair group had lower odds of developing incarceration (OR 0.43, 95% CI 0.34-0.54, p < 0.00001) but increased respiratory complications (OR 5.17, 95% CI 3.97-6.73, p < 0.00001) and recurrence rates (OR 3.25, 95% CI 1.18-8.92, p = 0.02) as compared to the delayed group. There were no statistically significant differences in testicular atrophy (OR 1.13, p = 0.91), iatrogenic ascending testis (OR 1.71, p = 0.61), postoperative hydrocele (OR 3.69, p = 0.21) or bowel injury (OR 1.16, p = 0.88) between early and delayed repair groups.
conclusionTiming of inguinal hernia repair requires balancing the risk of incarceration with anesthetic and recurrence concerns. Early hernia repair reduces incarceration but is associated with higher rates of respiratory complications and recurrence.
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