Evidence map›Paper›PMID 40714923›Full record

ArticleBrain and behavior2025

Functional Connectivity Changes in Primary Motor Cortex Subregions of Patients With Obstructive Sleep Apnea.

Lifeng Li, Qimeng Shi, Bowen Fang, Yuting Liu, Xiang Liu, Yongqiang Shu, Yingke Deng, Yumeng Liu, Haijun Li, Junjie Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lifeng LiJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID https://orcid.org/0000-0001-9817-7661
Qimeng ShiSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, China.
Bowen FangHengyang Medical School, University of South China, Hengyang, China.
Yuting LiuDepartment of Ophthalmology, Hunan Children's Hospital, Changsha, China.
Xiang LiuJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yongqiang ShuJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yingke DengJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yumeng LiuJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Haijun LiJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID https://orcid.org/0000-0001-6631-123X
Junjie ZhouDepartment of Radiology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Dechang PengJiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

Clinical Research Center For Medical Imaging In Jiangxi Province 20223BCG74001Department of Health Project of Jiangxi Province 202210211Jiangxi Province Key Laboratory for Precision Pathology and Intelligent Diagnosis 2024SSY06281National Natural Science Foundation of China 81860307Natural Science Foundation Project of Jiangxi Province 20181ACB20023The Key Research and Development Projects of Jiangxi Province 20243BBI91031
6 · The paper itself

Abstract

background and purposeObstructive sleep apnea (OSA) is linked to cognitive impairment and altered motor-related brain networks. This study examined functional connectivity (FC) changes in subregions of the primary motor cortex (M1) in patients with OSA and their association with sleep structure, cognition, and clinical features.

methodsSixty-five patients with OSA and 65 healthy controls (HC) participants matched in age and educational background were included. Resting-state functional MRI data were acquired for all participants using a 3T MRI system. Based on the Human Brainnetome Atlas, we analyzed FC changes of 12 subregions of M1 across the whole brain in patients with OSA. The two-sample t-tests were conducted to compare FC values between subregions of M1 and other brain regions in two groups. Partial correlation analyses examined the association between FC and clinical variables in patients with OSA. Additionally, we employed three machine learning algorithms-support vector machine (SVM), random forest (RF), and logistic regression (LR)-to distinguish patients with OSA from HC based on FC features.

resultsCompared to HC, the OSA group found that significant FC enhancements were identified in right A6cdl with the left inferior parietal lobule (IPL); left A4tl with the left inferior frontal gyrus (IFG), bilateral middle frontal gyrus (MFG), and left IPL; and left A6cvl with the right parahippocampal gyrus, bilateral MFG, left IFG, left superior temporal gyrus, and right cingulate gyrus. After Bonferroni correction, a negative correlation was observed between the FC value of A4tl (L)-IPL (L) and N2 (p < 0.05). Furthermore, SVM yielded the highest area under the receiver operating characteristic (ROC) curve (AUC) among all classifiers, indicating its superior performance in discriminating OSA patients from HC based on FC features.

conclusionThe study demonstrates that OSA significantly impacts brain functional networks, particularly affecting motor control through altered FC in subregions of M1. These alterations correlate with upper airway dysfunction and cognitive impairments, increasing accident risks. The high-accuracy SVM classification based on FC patterns demonstrates potential as a diagnostic biomarker for OSA. Future research should explore M1 FC patterns as diagnostic markers and neuromodulation therapies.

Indexed as

Motor CortexSleep Apnea, ObstructiveAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeural Pathwaysfunctional connectivityobstructive sleep apneaprimary motor cortexsubregionsupport vector machine

Identifiers

PMID40714923
PMCPMC12409839

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.