Evidence map›Paper›PMID 40714915›Full record

ArticleChemistry & biodiversity2025

Synthesis, Molecular Docking, and Biological Studies of New Naphthalene-1,4-Dione-Linked Phenylpiperazine and Thioether.

Berrin Yilmaz, Nahide Gulsah Deniz, Cigdem Sayil, Ozlem Bingol Ozakpinar, Merve Gurboga, Turgut Sekerler, Pervin Rayaman, Erkan Rayaman, Elif Caliskan Salihi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Berrin YilmazFaculty of Engineering, Department of Chemistry, Division of Organic Chemistry, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Nahide Gulsah DenizFaculty of Engineering, Department of Chemistry, Division of Organic Chemistry, Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-7977-7274
Cigdem SayilFaculty of Engineering, Department of Chemistry, Division of Organic Chemistry, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Ozlem Bingol OzakpinarFaculty of Pharmacy, Department of Biochemistry, Marmara University, Basibuyuk Campus, Istanbul, Turkey.
Merve GurbogaInstitute of Health Sciences, Department of Biochemistry (Pharmacy), Marmara University, Basibuyuk Campus, Istanbul, Turkey.
Turgut SekerlerFaculty of Pharmacy, Department of Biochemistry, Marmara University, Basibuyuk Campus, Istanbul, Turkey.
Pervin RayamanFaculty of Pharmacy, Department of Pharmaceutical Microbiology, Marmara University, Basibuyuk Campus, Istanbul, Turkey.
Erkan RayamanFaculty of Pharmacy, Department of Pharmaceutical Microbiology, Marmara University, Basibuyuk Campus, Istanbul, Turkey.
Elif Caliskan SalihiFaculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Marmara University, Basibuyuk Campus, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quinones are an important family of chemical compounds that are used in the development of anticancer drugs. Due to the anticancer properties of quinones, this study aims to investigate the antiproliferative and antimicrobial activities of newly substituted quinone derivatives synthesized through reactions with various nucleophiles (such as thiols and amines). The antiproliferative effects of the synthesized compounds on human cancer cell lines were screened at a concentration of 10 µM using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The cytotoxic effects of the synthesized compounds were also assessed in NIH/3T3 cells. Target molecules for the cancer cell lines A549, PC-3, and MCF-7 employed in this study were identified in light of the literature in order to perform molecular docking studies based on the MTT experiment results. Moreover, the antimicrobial effects of newly synthesized quinone derivatives were also investigated. Among the synthesized compounds, especially compound 10 had strong antiproliferative effects on a variety of cancer cell lines, most notably PC-3, while having no cytotoxicity toward NIH/3T3 cells. Furthermore, compounds 5 and 8 exhibited antimicrobial activity against both bacteria and fungi. Our results indicate that the newly synthesized quinone molecules may function as therapeutic agents for the treatment of cancer and infectious diseases.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsMolecular Docking SimulationNaphthalenesPiperazinesSulfidesAnimalsBacteriaCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorFungiHumansMiceAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsNaphthalenesphenylpiperazinePiperazinesQuinonesSulfidesanticancer activityantimicrobial activitymolecular dockingnaphthoquinonespectroscopy

Identifiers

PMID40714915
PMCPMC12629165

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.