Evidence map›Paper›PMID 40714907›Full record

ArticleESC heart failure2025

Prognostic value of longitudinal strain relative apical sparing in severe aortic stenosis patients undergoing TAVR.

Dan Liu, Kai Hu, Vera Schimpf, Victoria Sokalski, Friederike Hermann, Björn Daniel Lengenfelder, Georg Ertl, Stefan Frantz, Peter Nordbeck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan LiuDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Kai HuDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Vera SchimpfDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Victoria SokalskiDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Friederike HermannDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Björn Daniel LengenfelderDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Georg ErtlDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Stefan FrantzDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Peter NordbeckDepartment of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0002-2560-4068

Funding

Bundesministerium für Bildung und Forschung BMBF 01EO1504
6 · The paper itself

Abstract

aimsThis study evaluated the prognostic value of the relative apical sparing pattern (RASP) of longitudinal strain (LS) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) and investigated whether its combination with pre-procedural biomarkers enhances risk stratification. METHODS AND

resultsThis retrospective study included 598 patients (mean age 81.7 ± 5.7 years, 48.8% male) with severe AS undergoing TAVR. Two-dimensional speckle-tracking echocardiography was used to assess LS. RASP was defined as an apical-to-basal LS ratio >3.0 in ≥3 out of six left ventricular walls. The primary endpoint was 2-year cardiovascular (CV) mortality. RASP was present in 19.2% of patients and independently predicted 2-year CV mortality (hazard ratio [HR] 2.01, 95% CI 1.22-3.29, P = 0.006). Low serum albumin (<4.0 g/dL; HR 2.40, 95% CI 1.50-3.84, P < 0.001) and low BMI (≤25.5 kg/m

conclusionsRASP, particularly when combined with hypoalbuminemia and low BMI, identifies a high-risk phenotype associated with adverse outcomes after TAVR. This integrated risk model may assist in guiding pre-procedural assessment and individualized management.

Indexed as

Aortic ValveAortic Valve StenosisHeart VentriclesTranscatheter Aortic Valve ReplacementVentricular Function, LeftAgedAged, 80 and overEchocardiographyFemaleFollow-Up StudiesHumansMalePrognosisRetrospective StudiesRisk AssessmentSeverity of Illness IndexHeart failureHypoalbuminemiaLongitudinal strainRelative apical sparingTranscatheter aortic valve replacement

Identifiers

PMID40714907
PMCPMC12450792

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.