ArticleNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2025
Treatment outcomes in pediatric intestinal failure patients with ambulatory Candida central line-associated bloodstream infections with and without central venous line removal: A retrospective case series.
Article in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Treatment outcomes in pediatric intestinal failure patients with ambulatory Candida central line-associated bloodstream infections with and without central venous line removal: A retrospective case series.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLack of central venous line (CVL) sites is a common indication for intestinal transplantation in intestinal failure (IF) patients. For treatment of central line-associated bloodstream infections (CLABSIs), many pediatric gastroenterologists preserve CVL access, but line removal is typically recommended for Candida sp CLABSI due to high risk of systemic complications. However, no data exist on outcomes for IF patients treated for Candida sp CLABSI. This study aims to assess if CVL preservation increases the risk of complications or recurrence. MATERIALS AND
methodsA retrospective chart review was conducted for children <18 years of age with IF and Candida sp CLABSI between 2012 and 2023. Patients with blood cultures positive for Candida sp from the CVL were included. Each CLABSI event was analyzed for key variables.
resultsTwelve patients were included, with 18 events (median age 6.4 years). Candida species identified included C albicans (33.3%) and C parapsilosis (38.9%). Antifungal therapy exceeded 14 days in all events, and ethanol lock therapy (70% concentration) was used in 72%. CVL was removed in 44.4% of events. Five patients had multiple events, with Candida species identified in subsequent infections. No secondary site seeding or long-term sequelae occurred, and no patients died.
conclusionOur data suggest that CVL preservation in pediatric IF patients with Candida sp CLABSI is feasible without increased complications or mortality. Limitations include small sample size and retrospective design.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.