ArticlePhysiological reports2025
Exercise duration and detraining influence not only body weight but also histopathological changes in the white adipose tissue of young male OLETF rats as an obesity model.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Environmental exposures during early life impact health and disease in later life. Therefore, understanding the effects of exercise during early life and detraining on obesity in adulthood may be valuable for preventing and treating obesity. This study aimed to examine the effects of short- and long-term exercise and detraining during early life on the histological changes in adulthood. Four-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF) rats were used as an animal model of obesity. The OLETF rats were divided into the sedentary and exercise groups. The rats in the exercise group were further divided into two subgroups according to the exercise period: exercised from 4- to 8-week-old and non-exercised from 8- to 20-week-old, and exercised from 4- to 12-week-old and non-exercised from 12- to 20-week-old. The metabolic profiles in adulthood, such as body weight, did not significantly differ between rats subjected to short- and long-term exercise during the young period. However, histological changes in white adipose tissue, such as adipocyte hypertrophy and chronic inflammation, were effectively reduced with long-term exercise compared with short-term exercise. Long-term exercise during the young period resulted in low adiposity in adulthood, although no significant differences in body weight after detraining were observed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.