Evidence map›Paper›PMID 40714829›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Osteoblast-CD4

Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Osteoblast-CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Bin YangDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Guofu ZhangNorthern Jiangsu People's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Yangzhou, 225001, China.
Yizhou ZhuDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 999077, China.
Jingcheng WangDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Xinmin FengDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Wenyong FeiDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Jihang DaiDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Le HuDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Yi ZhangDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Jun CaiDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Binjia RuanNorthern Jiangsu People's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Yangzhou, 225001, China.
Yue JinDepartment of Medical Research Center, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
Fanhao WeiThe Yangzhou School of Clinical Medicine of Dalian Medical University, Yangzhou, 225001, China.
Gang LuCUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Dongan WangDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.
Jason Pui Yin CheungDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 999077, China.
Graham Ka Hon SheaDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 999077, China.
Hao ChenInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225000, China.
Kelvin Wai Kwok YeungDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 999077, China.ORCID https://orcid.org/0000-0003-0887-088X
Lei WangNorthern Jiangsu People's Hospital, Yangzhou, 225001, China.
Yongxiang WangDepartment of Orthopaedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.

Funding

Frontier Technology Research and Development Program of Jiangsu Province BF2024044Lvyang Jinfeng Talent Project of Yangzhou City YZLYJFJH2022WSCX003National Key Research and Development Program of China 2023YFB3810200National Key Research and Development Program of China 2023YFB3810204National Natural Science Foundation of China 82272502,82072423Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX21_3288
6 · The paper itself

Abstract

The dynamic production and clearance of senescent osteoblasts affects bone homeostasis and health. However, the relationship between senescent osteoblasts and the immune system remains unclear. Here, a landscape of the interaction between immune cells and osteoblasts through spatial analysis of the bone microenvironment is presented. Sirtuin 1 (SIRT1), a longevity gene, regulates bone mass maintenance through a mechanism involving osteoblast-CD4

Indexed as

CD4-Positive T-LymphocytesOsteoblastsOsteoporosisSirtuin 1T-Lymphocytes, CytotoxicAnimalsHumansMiceMice, Inbred C57BLSIRT1 protein, humanSirt1 protein, mouseSirtuin 1bone homeostasisCD4+ cytotoxic T lymphocytechemokine signallingDAAM2osteoblastosteoporosisSIRT1

Identifiers

PMID40714829
PMCPMC12533366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.