Evidence map›Paper›PMID 40714825›Full record

ArticleAdvanced healthcare materials2025

Biomimetic, Suturable, and Extensible Electrospun Scaffolds for Lower Urinary Tract Surgical Reconstruction.

Renea M Sturm, Yadi Huo, Felix Yiu, Yimin Gu, Ronak Afshari, Zijian Zhong, Ruby Jimenez, Rebekah Jung, Aljohn Cabuan, Keshav Shukla and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Renea M SturmDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID https://orcid.org/0000-0001-8030-5637
Yadi HuoDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Felix YiuDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Yimin GuDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Ronak AfshariDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Zijian ZhongDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Ruby JimenezDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Rebekah JungDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Aljohn CabuanDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Keshav ShuklaDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Karen HarrisonDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Judy SuCalifornia NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, 90095, USA.
George E AninweneDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Victoria LeeDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Mahsa GhovvatiDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Kaavian ShariatiDepartment of Urology, Division of Pediatric Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Nicholas JacksonDepartment of Medicine Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90024, USA.
Song LiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Funding

Highly Elastic Biomaterial Development for Urethral ApplicationK08DK134868 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Renea Sturm · 2023 to 2026
$680k
NIDDK NIH HHS K08 DK134868
6 · The paper itself

Abstract

Common autologous tissue sources used for the repair or replacement of lower urinary tract (LUT) organs include the inner cheek (buccal), small and large bowels, and foreskin. These sources have limited availability, introduce the risk of donor site complications, and differ mechanically and biologically from LUT tissue. To address this, fibrous composite scaffolds with varying ratios of two naturally derived polymers-gelatin methacryloyl and an elastin-like peptide-are fabricated via electrospinning and photo-crosslinking. Among the tested ratios, 5:5% (w/v) elastin-like peptide-gelatin methacryloyl (5E5G) fibrous scaffolds are suturable and most closely replicate LUT tissue, exhibiting a tensile modulus of 25.6 ± 4.77 kPa, an ultimate tensile strength of 41 ± 6.68 kPa, and an elongation of 167.4% ± 5.41%. Furthermore, the 5E5G scaffold exhibits a mean degradation exceeding 50% after 21 days in 37 °C Dulbecco's Phosphate Buffered Saline. In vitro, smooth muscle and fibroblast proliferation is robust on both 0E10G and 5E5G scaffolds, whereas urothelial cells display lower relative proliferation. In vivo subcutaneous implantation in rats demonstrates biocompatibility and supports tissue ingrowth without local fibrosis or inflammatory responses, similar to a sham injury model. Collectively, 5E5G electrospun scaffolds represent promising substrates for enhancing LUT tissue regeneration.

Indexed as

Biomimetic MaterialsPlastic Surgery ProceduresTissue ScaffoldsUrinary TractAnimalsCell ProliferationElastinFibroblastsGelatinHumansMethacrylatesRatsTensile StrengthTissue EngineeringElastinGelatingelatin methacryloylMethacrylatesbiocompatible materialsbiomechanicselastin‐like polypeptidestissue engineeringtissue scaffoldsurethral reconstructionurinary bladder

Identifiers

PMID40714825
PMCPMC12477578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.