ReviewSmall (Weinheim an der Bergstrasse, Germany)2025
The Challenges and Opportunities of Protein Coronas for Nanoscale Biomolecular Sensing.
Review in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Carbon Quantum Dots-Enhanced Polyvinyl Alcohol: A Comprehensive Approach to Food Preservation.Comprehensive reviews in food science and food safety · 2026Review
- In Situ Biosynthesis of Pd Nanocrystals in Bifidobacterium Bioreactor as Dual Immune Stimulators for Immuno-Chemodynamic Therapy of Cold Tumor.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Advancements in Nanomaterial-Based Biosensors for Neuropsychiatric and Neurodegenerative Diagnostics: From Biomarker Discovery to Clinical Translation.Biosensors · 2026Review
- Polymeric Nanogels for Skin Applications.Gels (Basel, Switzerland) · 2026Review
- The Challenges and Opportunities of Protein Coronas for Nanoscale Biomolecular Sensing.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The unique benefits of sub-picomolar and single-molecule detection for the diagnosis and prognosis of diseases and therapeutic efficacy monitoring have been driving the development of nanoscale biomolecular sensors. Nanoscale sensors can be attached to the surface or dispersed in solution, enabling the rapid detection of analytes with high sensitivity and specificity by overcoming concentration-driven diffusion limits. In biological fluids, however, nanoscale objects are surrounded by biomolecules, mostly proteins, that form an evolving encapsulating surface layer, commonly known as the protein corona. The protein corona can modify the biosensor surface, which can adversely impact biosensing specificity, sensitivity, and accuracy. Conversely, the protein corona can be exploited to design biosensors for disease diagnostics, the discovery of new biomarkers, and environmental contaminants. In this review, the factors influencing protein corona formation on nanoscale biosensors are examined. Characterization methods and the effects of protein corona formation on the performance of nanoscale biosensors are also discussed. Promising strategies to prevent, circumvent, and exploit corona formation are presented and this review concludes by outlining future perspectives of nanoscale biomolecular sensors for practical application in biological fluids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.