ArticleBone2025
Evaluating the usage of human placental tissue-derived xenograft in a surgically induced murine fracture model.
Article in Bone, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Impaired bone fracture healing can lead to chronic pain, loss of function, or life-long complications which can lead to limb-amputation. This study evaluated the effectiveness of human placental tissue-derived xenograft preparations (Connective Tissue Matrix, [CTM Biomedical®]) in promoting bone healing and reducing post-fracture pain behaviors using a preclinical, surgically induced, murine fracture model. CTM is thought to contain structural proteins and growth factors important for fracture healing. An intramedullary nail was used to stabilize the femur, and a mid-shaft femoral fracture was induced in 12-week-old male C57BL/6 J mice. Mice were divided into four groups (Saline Control, CTM Membrane, CTM Paste, and CTM Membrane + Paste). Complete blood count (CBC) and pain behavioral assessments were performed weekly. Modified radiographic union for tibial fracture (mRUST) scoring was used to assess healing from bi-weekly X-rays. Mice were euthanized 23 days post-fracture (dpf), and femurs were collected for μCT analysis and biomechanical or histomorphometric analyses. No significant changes in CBC were observed in any group. Compared to Saline Control, CTM Membrane (p = 0.002) and CTM Membrane + Paste (p = 0.04) treated groups exhibited a reduced pain score 4 dpf (grimace scores). μCT and histomorphometry showed that CTM Membrane + Paste group had significantly higher callus area (p = 0.01) and % bone (p = 0.001) compared to Saline Controls. mRUST scores, endomucin staining, and biomechanical outcomes between groups were not different. Preclinical findings suggest that CTM Membrane + Paste exhibits potential in enhancing bone healing. CTM products also do not increase pain behaviors in the surgical fracture model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.