Evidence map›Paper›PMID 40714053›Full record

ReviewJournal of molecular biology2025

Synergistic Methods to Investigate Eukaryotic Translation and Its Quality Control.

Aubrey J Emmi, Adrian S McFarland, Morgan M Grimes, Izaiah J Cole, Michael R Lawson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aubrey J EmmiDepartment of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Adrian S McFarlandDepartment of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Morgan M GrimesDepartment of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Izaiah J ColeDepartment of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Michael R LawsonDepartment of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA. Electronic address: michaelrlawson@ucla.edu.

Funding

Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Chemistry Biology Interface Training ProgramT32GM136614 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Patrick G. Harran · 2020 to 2026
$2.8M
Dynamic interplay of eukaryotic translation and mRNA decayR00GM140209 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAWSON, MICHAEL R · 2023 to 2025
$747k
NIGMS NIH HHS R00 GM140209NIGMS NIH HHS T32 GM136614NIGMS NIH HHS T32 GM145388
6 · The paper itself

Abstract

Eukaryotic translation is a highly regulated cellular process that not only directs the synthesis of proper polypeptides, but also helps to ensure the timely decay of faulty transcripts. In this review, we highlight the interdisciplinary approaches that have yielded key insights into mechanisms of the latter stages of eukaryotic translation and associated quality control pathways in the past decade. Synergies of these approaches are demonstrated through examination of recent discoveries regarding translation termination, ribosomal recycling, Nonsense-Mediated mRNA Decay, and No-Go Decay. In the long run, a detailed understanding of how translation concludes on normal and defective transcripts has the potential to inform the development of novel therapeutics for many hereditary diseases.

Indexed as

Eukaryotic CellsProtein BiosynthesisAnimalsHumansNonsense Mediated mRNA DecayRibosomesRNA, MessengerRNA, MessengermRNArecyclingribosometerminationtranslation

Identifiers

PMID40714053
PMCPMC12599860

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.