Evidence map›Paper›PMID 40714049›Full record

Trial reportThe Journal of pediatrics2025

Severity of Bronchopulmonary Dysplasia in Infants Born Extremely Preterm and Randomized to Early Human Milk Fortification with a Donor Milk-Derived Fortifier for 2 Weeks.

Marley J Tucker, Seabrook H Jeffcoat, Tori Argent, Colm P Travers, Ariel A Salas

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04325308 (Early Life Protein-enriched Human Milk Diets to Increase Lean Body Mass Accretion and Diversity of the Gut Microbiome in Extremely Preterm Infants), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04325308 naactive not recruitingnot on this map

Early Life Protein-enriched Human Milk Diets to Increase Lean Body Mass Accretion and Diversity of the Gut Microbiome in Extremely Preterm Infants: a Randomized Trial

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2020 to 2027Enrolled150ConditionsPrematurity, Extreme, Feeding Disorder Neonatal, Breast Milk ExpressionArmsProtein-enriched human milk diet, Usual human milk diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marley J TuckerDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Seabrook H JeffcoatDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Tori ArgentDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Colm P TraversDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Ariel A SalasDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. Electronic address: asalas@uab.edu.

Funding

Non-invasive oscillometry to measure lung mechanics, response to treatments, and predict longer-term pulmonary outcomes among preterm infants: a prospective cohort studyK23HL157618 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Colm Peter Travers · 2022 to 2026
$862k
Early life protein-enriched human milk diets to increase lean body mass accretion and diversity of the gut microbiome in extremely preterm infants: a randomized trialK23HD102554 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SALAS, ARIEL · 2020 to 2024
$774k
NHLBI NIH HHS K23 HL157618NICHD NIH HHS K23 HD102554
6 · The paper itself

Abstract

In this secondary analysis of a masked clinical trial involving 150 infants born extremely preterm randomized to receive fortified milk starting on either postnatal day 3 (early group) or day 14 (delayed group), we found a significant difference in the distribution of bronchopulmonary dysplasia severity between the 2 groups (P = .039) with milder forms of bronchopulmonary dysplasia in the early group.

Indexed as

Bronchopulmonary DysplasiaFood, FortifiedInfant, Extremely PrematureMilk, HumanFemaleHumansInfant, NewbornMaleSeverity of Illness Indexcritical illnessenteral nutritioninfant chronic lung diseasemechanical ventilationsupplemental oxygen

Identifiers

PMID40714049
PMCPMC12382184

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.