Evidence map›Paper›PMID 40714046›Full record

Trial reportThe Journal of pediatrics2025

Early Vitamin D Supplementation in Infants Born Extremely Preterm and Fed Human Milk: A Randomized Controlled Trial.

Ariel A Salas, Tori Argent, Seabrook Jeffcoat, Marley Tucker, Ambika P Ashraf, Colm P Travers

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05615311 (Respiratory Outcomes After Early Vitamin D Supplementation in Infants Born Extremely Preterm), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05615311 phase1 / phase2active not recruitingnot on this map

Respiratory Outcomes After Early Vitamin D Supplementation in Infants Born Extremely Preterm: A Randomized Trial

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2023 to 2027Enrolled126ConditionsPrematurity, ExtremeArmsVitamin D supplementation, No additional vitamin D supplementation
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ariel A SalasDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. Electronic address: asalas@uab.edu.
Tori ArgentDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Seabrook JeffcoatDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Marley TuckerDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Ambika P AshrafDivision of Pediatric Endocrinology & Diabetes, University of Alabama at Birmingham, Birmingham, AL.
Colm P TraversDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.

Funding

Non-invasive oscillometry to measure lung mechanics, response to treatments, and predict longer-term pulmonary outcomes among preterm infants: a prospective cohort studyK23HL157618 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Colm Peter Travers · 2022 to 2026
$862k
Early life protein-enriched human milk diets to increase lean body mass accretion and diversity of the gut microbiome in extremely preterm infants: a randomized trialK23HD102554 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SALAS, ARIEL · 2020 to 2024
$774k
NHLBI NIH HHS K23 HL157618NICHD NIH HHS K23 HD102554
6 · The paper itself

Abstract

objectiveTo evaluate the effects of vitamin D supplementation on short-term respiratory outcomes in infants born at 28 weeks of gestation or less and fed human milk. STUDY

designThis masked, randomized controlled trial included infants born extremely preterm and fed human milk in 2023-2024. Infants received either 800 IU/day vitamin D (intervention) or no additional vitamin D (control) for the first 14 days. Masking was maintained by adding 800 IU of vitamin D to daily feedings. The primary outcome was severity of bronchopulmonary dysplasia (BPD) at 36 weeks of postmenstrual age. Secondary outcomes included reactance and resistance (R

resultsA total of 126 infants were randomized (mean birthweight: 759 ± 228 g; 52% female). The intervention increased 25-hydroxy vitamin D3 concentrations (mean difference: +29 ng/mL; P < .0001). The severity of BPD did not differ between groups (P = .60). area under the reactance curve measurements were comparable (674 ± 207 vs 694 ± 240; P = .64) and R

conclusionsAdministering 800 IU/day of vitamin D during the first 2 weeks did not reduce BPD severity but may contribute to improved bone health.

trial registrationClinicalTrials.gov: NCT05615311. https://clinicaltrials.gov/study/NCT05615311.

Indexed as

Bronchopulmonary DysplasiaDietary SupplementsInfant, Extremely PrematureMilk, HumanVitamin DVitaminsFemaleHumansInfant, NewbornMaleVitamin D DeficiencyVitamin DVitaminsbronchopulmonary dysplasiacalcium metabolismenteral nutritionosteopenia of prematuritypremature newbornvitamin D deficiency

Identifiers

PMID40714046
PMCPMC12315824

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.