Emerging Insights into Protein Post-Translational Modifications in Chlamydia-Host Interactions.

Xiang Luo, Xin Wang, Canming Hu, Zhe Liu, Chunxue Lu, Shenghua Chen, Qinqin Bai, Xindian Zeng, Lili Chen

Abstract readReview

In one paragraph

Review in The American journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

The distinct trimeric structure of the immunodominant chlamydial antigen Major Outer Membrane Protein.Nature communications · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiang LuoDepartment of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.

Xin WangDepartment of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.

Canming HuDepartment of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.

Zhe LiuDepartment of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.

Chunxue LuSchool of Basic Medicine, Hengyang Medical School, University of South China, Hengyang, China.

Shenghua ChenSchool of Basic Medicine, Hengyang Medical School, University of South China, Hengyang, China.

Qinqin BaiDepartment of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.

Xindian ZengDepartment of Medical Record, Affliated Nanhua Hospital, University of South China, Hengyang, China.

Lili ChenDepartment of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China. Electronic address: chlili720612@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chlamydia species are responsible for significant diseases in both humans and animals, with their infection processes involving complex interactions with host cells. Protein post-translational modifications (PTMs) have emerged as a critical focus in understanding the complex interplay between Chlamydia and its host. PTMs, including phosphorylation, glycosylation, ubiquitination, acetylation, and methylation, play pivotal roles in regulating key processes during Chlamydia infection, such as bacterial invasion, intracellular survival, immune evasion, and manipulation of host signaling pathways. By modulating both bacterial and host proteins, PTMs serve as essential mechanisms that shape the progression and outcome of Chlamydia infections. This growing area of research not only deepens the understanding of Chlamydia's pathogenic strategies but also opens new avenues for developing targeted therapeutic interventions against these infections.

Indexed as

ChlamydiaChlamydia InfectionsHost-Pathogen InteractionsProtein Processing, Post-TranslationalAnimalsHumans

Identifiers

PMID40713979

DOI10.1016/j.ajpath.2025.06.011

PMCPMC12597473

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.