ArticleCell reports2025
Transformation of radial glia into postnatal neural stem cells depends on birth.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Single-Cell Atlas Uncovers Layer 4 Heterogeneity and Functional Gradients in Rhesus Macaque Visual Cortex.bioRxiv : the preprint server for biology · 2025Article
- Preterm Birth Causes Decreased Postnatal Neurogenesis: A Novel Mechanism Underlying Adverse Neurodevelopmental Outcomes.Pediatrics international : official journal of the Japan Pediatric SocietyReview
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Authors and funding
16 authors.
Funding
Abstract
A common feature of various postnatal stem cells is their close association with blood vessels. Postnatal neural stem cells (NSCs) in the ventricular-subventricular zone originate from fetal radial glia (RG), which possess NSC properties. Here, using live imaging and three-dimensional (3D) electron microscopy, we investigated how RG convert into postnatal NSCs and characterized the fine 3D morphology of the ventricular-subventricular zone. We found that preterm birth disrupts RG-endothelial cell interactions during this transformation, impairing both the structure and stemness of adult NSCs. These findings underscore the importance of a birth-dependent transformation. Our results indicate that RG fiber transection, which depends on the birth process, and endfoot formation on blood vessels, which depends on birth timing, are both critical steps in the conversion of RG into adult NSCs.
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Registered trials
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