Evidence map›Paper›PMID 40713943›Full record

ArticleCurrent biology : CB2025

Ca

Takaya Totsuka, Miho Ohsugi, Takashi Akera

Abstract read
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Takaya TotsukaCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: takaya.totsuka@nih.gov.
Miho OhsugiDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Takashi AkeraCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: takashi.akera@nih.gov.

Funding

Laboratory of Chromosome Dynamics and EvolutionZIAHL006249 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI AKERA, TAKASHI · 2020 to 2025
$12.1M
Intramural NIH HHS ZIA HL006249
6 · The paper itself

Abstract

Female meiosis is highly asymmetric, producing a large egg and a small polar body to preserve maternal storage essential for embryogenesis. To achieve asymmetric division, the egg spindle must maintain its cortical position until fertilization completes meiosis. In mice, fertilization triggers chromosome segregation, followed by spindle rotation to achieve the perpendicular orientation relative to the cortex, leading to the extrusion of one set of chromosomes. However, it was unknown how the spindle maintains its cortical position while rotating. Here, we developed a high-resolution live-imaging method to investigate spindle dynamics during fertilization. Our results indicate that Ca

Indexed as

CalciumCalcium SignalingCytoplasmic StreamingFertilizationSpindle ApparatusZygoteAnimalsChromosome SegregationCytoplasmFemaleMaleMeiosisMiceCalciumactomyosin contractionCa(2+) oscillationscytoplasmic streamingfertilizationlive imagingmeiosis IImouse eggsecond polar body extrusionspindle dynamics

Identifiers

PMID40713943
PMCPMC12421433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.