SynthesisItalian journal of pediatrics2025
A meta-analysis on the predictive role of CRP in NEC diagnosis and prognosis.
Synthesis in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Biomarkers for Necrotising Enterocolitis-Are We There Yet?Children (Basel, Switzerland) · 2026Review
- Sepsis in neonates with necrotizing enterocolitis: outcomes and predictive model.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- RPS29 as a potential early diagnostic biomarker for necrotizing enterocolitis: validation from transcriptomic and proteomic cohorts.Translational pediatrics · 2026Article
- Necrotizing enterocolitis.Nature reviews. Disease primers · 2026Review
- [Multicenter prospective study on the diagnostic value of syndecan-1 for necrotizing enterocolitis in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Serum LRG1 as a diagnostic marker of necrotizing enterocolitis in preterm infants.Frontiers in pediatrics · 2026Article
- Platelet-to-C-reactive protein ratio stratifies surgical risk and mortality in necrotizing enterocolitis neonates with portal venous gas.Frontiers in pediatrics · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to evaluate the role of C-reactive protein (CRP) in necrotizing enterocolitis (NEC) diagnosis and prognosis through a systematic review and meta-analysis.
methodsA comprehensive search was conducted across PubMed, Cochrane Library, Embase, and Web of Science databases to identify relevant studies on CRP and NEC. Outcomes included correlations between CRP levels and NEC occurrence, surgical intervention, severity, and intestinal strictures.
resultsA total of 30 studies were included in the analysis. Data from categorical variables indicated a significant positive association between CRP and the incidence of NEC (OR: 3.5, 95% CI: 2.23-5.49), while continuous variables revealed a significant difference in CRP levels between the NEC and non-NEC groups (SMD: 2.61, 95% CI: 1.72-3.5). Elevated CRP levels were significantly correlated with an increased risk of surgery, with a notable difference in CRP levels between the surgical and non-surgical groups. CRP levels were also positively associated with the risk of NEC progression, and a significant difference was observed between the progression and non-progression groups. Besides, a significant difference in CRP levels was observed between the stricture and non-stricture groups. Subgroup analysis indicated that CRP has a higher predictive value in infants with NEC who had a gestational age greater than 28 weeks and a birth weight exceeding 1500 g.
conclusionCRP has significant clinical value in predicting the occurrence of NEC, disease progression, and the timing of surgical intervention.
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