Evidence map›Paper›PMID 40713717›Full record

ArticleJournal of ovarian research2025

Ovarian aging, cardiovascular risk and inflammation: insights from the OVA study.

C Verhaeghe, K J Lindquist, M E Bleil, M Rosen, R F Redberg, D Haisenleder, C E McCulloch, Marcelle I Cedars

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

C VerhaegheDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, 499 Illinois St., 6th Floor, Box 0916, San Francisco, CA, 94158, USA.
K J LindquistDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, 499 Illinois St., 6th Floor, Box 0916, San Francisco, CA, 94158, USA.
M E BleilChild, Family, and Population Health Nursing, School of Nursing, University of Washington, Seattle, WA, 98195, USA.
M RosenDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, 499 Illinois St., 6th Floor, Box 0916, San Francisco, CA, 94158, USA.
R F RedbergPhilip R Lee Institute for Health Policy Studies, San Francisco, CA, USA.
D HaisenlederUVA Center for Research in Reproduction, Ligand Core, University of Virginia, Charlottesville, VA, USA.
C E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Marcelle I CedarsDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, 499 Illinois St., 6th Floor, Box 0916, San Francisco, CA, 94158, USA. Marcelle.Cedars@ucsf.edu.

Funding

Longitudinal Evaluation of Ovarian Aging and Cardiovascular RiskR01AG053332 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CEDARS, MARCELLE IVONNE · 2017 to 2022
$7.1M
National Institutes of Health (NIH) 1R01AG53332-01A1NIA NIH HHS R01 AG053332
6 · The paper itself

Abstract

backgroundCardiovascular disease is the leading cause of death among women and is associated with both metabolic syndrome and ovarian aging. Chronic inflammation has been proposed as a potential common underlying mechanism linking these conditions. This study aimed to examine the associations between inflammatory markers (interleukin-6, tumor necrosis factor-alpha, high-sensitivity C-reactive protein) and metabolic syndrome, with markers of ovarian aging and cardiovascular risk.

resultsIn the cross-sectional analysis of 829 women aged 25-45, no significant associations were found between inflammatory markers, metabolic syndrome, and ovarian aging measures (anti-Müllerian hormone [AMH] and antral follicle count [AFC]), except for a modest association between metabolic syndrome and AMH (mean difference 0.085; 95% CI: 0.035 to 0.134). Similarly, inflammatory markers and metabolic syndrome were not significantly associated with the Framingham Risk Score. In the longitudinal analysis of 307 participants, changes in AMH and AFC were not associated with inflammatory markers or metabolic syndrome. However, higher levels of IL-6 and TNF-α were associated with the Framingham Risk Score, whereas hsCRP and metabolic syndrome were not.

conclusionThese findings do not support the hypothesis that inflammation is a central mechanism linking ovarian aging to cardiovascular risk. The absence of consistent associations across analyses suggests that alternative pathways may underlie this relationship. Further research incorporating a broader range of biomarkers is warranted to elucidate the complex interactions between reproductive aging and cardiovascular health in women.

Indexed as

AgingCardiovascular DiseasesInflammationOvaryAdultAnti-Mullerian HormoneBiomarkersC-Reactive ProteinCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansInterleukin-6Metabolic SyndromeMiddle AgedRisk FactorsAnti-Mullerian HormoneBiomarkersC-Reactive ProteinInterleukin-6Tumor Necrosis Factor-alphaanti-Müllerian hormoneAntral follicle countCardiovascular risk.Chronic inflammationInflammatory biomarkersMetabolic syndromeOvarian aging

Identifiers

PMID40713717
PMCPMC12297770

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.