Evidence map›Paper›PMID 40713661›Full record

SynthesisEnvironmental health : a global access science source2025

Long-term exposure to elemental carbon and disease incidence: a systematic review and meta-analysis.

Maria-Iosifina Kasdagli, Dimitris Stamatiou, Antonis Analitis, Klea Katsouyanni, Mihalis Lazaridis, Maria I Gini, Konstantinos Eleftheriadis, Evangelia Samoli

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Environmental health : a global access science source, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria-Iosifina KasdagliDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, Athens, 115 27, Greece. kasdaglimar@gmail.com.
Dimitris StamatiouDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, Athens, 115 27, Greece.
Antonis AnalitisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, Athens, 115 27, Greece.
Klea KatsouyanniDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, Athens, 115 27, Greece.
Mihalis LazaridisSchool of Chemical and Environmental Engineering, Technical University of Crete, Chania, Greece.
Maria I GiniENRACT, Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety, N.C.S.R, Demokritos, Athens, Greece.
Konstantinos EleftheriadisENRACT, Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety, N.C.S.R, Demokritos, Athens, Greece.
Evangelia SamoliDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, Athens, 115 27, Greece.

Funding

European Union's Horizon Europe 101138449
6 · The paper itself

Abstract

introductionEpidemiological studies have documented the health effects of long-term exposure to fine particulate matter, while there is a growing number of studies looking into associations with one of its main components elemental carbon (EC) and its related metrics such as black carbon (BC), black smoke (BS) or aerosol light absorption coefficient often referred as "PM absorbance". We performed a systematic review and meta-analysis on the associations between long-term exposure to elemental carbon (EC) and disease incidence.

methodsWe searched for studies published up to April 2025, assessing long-term to EC-related exposure (also including BC, BS, PM absorbance) and incidence of ischemic heart disease (IHD), asthma, chronic obstructive pulmonary disease (COPD) and lung cancer in adults, and asthma and acute lower respiratory infections (ALRI) in children. We pooled effect estimates by random-effects models and investigated heterogeneity by region and risk of bias assessments. The certainty of the evidence was assessed using the Grading of Recommendations Assessment Development approach.

resultsWe included 51 studies assessing long-term exposure to EC and disease incidence. The pooled relative risk (RR) for a 1 µg/m

conclusionsOur meta-analysis supports an increased risk of lung cancer following long term exposure to EC and indicates associations for IHD in adults and respiratory outcomes in children. Although the evidence base on the effects of EC on diseases incidence has been increasing, further research is needed in the associations between long- term exposure to EC and various diseases' incidence.

Indexed as

Air PollutantsCarbonEnvironmental ExposureParticulate MatterHumansIncidenceLung NeoplasmsPulmonary Disease, Chronic ObstructiveAir PollutantsCarbonParticulate MatterElemental carbonIncidenceLong-term exposureMeta-analysis

Identifiers

PMID40713661
PMCPMC12291253

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.