Evidence map›Paper›PMID 40713650›Full record

SynthesisBMC oral health2025

Prognosis of intentional replantation for periapical periodontitis teeth: a systematic review and meta-analysis.

Baotian Zhang, Liandi Cheng, Xiangjin Deng, Yutao Xiong, Wei Liu, Wei Zeng, Wei Tang, Chang Liu

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Baotian Zhang *State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.ORCID http://orcid.org/0009-0007-5043-5618
Liandi Cheng *State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.ORCID http://orcid.org/0009-0003-8351-8437
Xiangjin Deng *State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.ORCID http://orcid.org/0009-0001-9769-4402
Yutao XiongState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.ORCID http://orcid.org/0000-0003-1257-4055
Wei LiuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.ORCID http://orcid.org/0000-0002-1470-3538
Wei ZengState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.ORCID http://orcid.org/0000-0002-4486-8798
Wei TangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. mydrtw@vip.sina.com.ORCID http://orcid.org/0000-0001-7568-2884
Chang LiuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. liu_chang_92@sina.com.ORCID http://orcid.org/0000-0002-1232-8308

Funding

National Health Commission Hospital Management Institute "Clinical Application Research Project on Medical Artificial Intelligence" Grant No. YLXX24AIA009Sichuan Science and Technology Program Grant No. 2024NSFSC0659West China Hospital of Stomatology Sichuan University Grant No. RD-03-202303
6 · The paper itself

Abstract

backgroundIntentional replantation (IR) includes extraction, subsequent treatment, and replantation of teeth. It is regarded as a final strategy to preserve teeth affected by periapical periodontitis. This review aims to evaluate the overall prognosis and key prognostic factors of IR for periapical periodontitis teeth.

methodsTen databases (Ovid MEDLINE, Ovid Embase, etc.) and two registers were searched up to June 2024. Two independent review authors selected and identified prognostic studies (both prospective and retrospective studies) involving patients with periapical periodontitis teeth undergoing IR, reporting on success and survival rates, and factors influencing outcomes. Then, two independent review authors extracted the characteristics of the included studies and assessed the bias using the QUIPS tool. Meta-analyses were undertaken wherever appropriate.

resultsA total of 39 studies (49 reports) with 2305 teeth were included in this review. 31 studies were judged as high risk of overall bias while the other eight at moderate risk. For overall prognosis, meta-analyses showed a pooled success rate of 0.78 (95% CI 0.70 to 0.84) and pooled survival rate of 0.89 (95% CI 0.85 to 0.93). For prognostic factors, survival rate ratio (SRR) of age was 0.73 (95% CI 0.53 to 0.99, p = 0.048), and SRR of combined periodontal-endodontic lesions (CPEL) was 0.80 (95% CI 0.67 to 0.95, p = 0.001). DISCUSSION: Results indicated that age and CPEL were significant factors influencing the success rate of IR, thereby supporting its clinical applicability in managing periapical periodontitis. The 39 cohort studies included in this review provided robust evidence for identifying the overall prognosis and key prognostic factors, which were the primary objectives of this study. However, the absence of large-sample cohort studies (both prospective and retrospective) reduces the reliability of the conclusions drawn in this review. Moreover, the observed variability across studies emphasizes the need for standardized protocols and further research to enhance consistency and reliability.

Indexed as

Periapical PeriodontitisTooth ReplantationHumansPrognosisEndodonticsEvidence-based medicineMeta-analysisPeriapical periodontitisSystematic reviewTooth ankylosisTooth replantation

Identifiers

PMID40713650
PMCPMC12297747

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.