ArticleBreast cancer research : BCR2025
Short-term consumption of the modified standard American diet perturbed the metabolic balance and altered DNA damage in MMTV-PyMT transgenic mice.
Article in Breast cancer research : BCR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Impact of high-fat Western diet on chronic lymphocytic leukemia disease progression and gut microbiome profile in Eµ-TCL1 mice.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundRisk factors for breast cancer include obesity and hyperglycemia, which are associated with poor survival. Previous studies have used high-fat diets (HFDs) or Western-style diets to model dietary influences on breast cancer progression. However, these diets do not reflect the energy-dense, nutrient-poor diets that Americans typically consume. To address this gap in our understanding of the interplay between diet and breast cancer progression, we examined the effects of a modified standard American diet (SAD2) on mammary tumorigenesis in the MMTV-PyMT transgenic murine model and their FVB/N controls.
methodsMMTV-PyMT and FVB/N mice were fed normal chow or the experimental diet SAD2 for up to 12 weeks. We evaluated body weight, blood glucose, adiposity, cytokine, and tumor characteristics to measure SAD2 diet-induced changes in breast tumor development.
resultsIncreased body weight and adiposity were observed in MMTV SAD2-treated mice, consistent with the findings of shorter-term HFD studies. The SAD2 diet also resulted in earlier tumor initiation and progression and decreased survival in the SAD2-fed mice. While only modest changes were observed in circulating cytokines and metabolic parameters, the SAD2 tumors presented significant changes in oxidative DNA damage and advanced glycation end products (AGEs). These changes coincided with increases in the oncogenic transcription factor Foxm1 and the expression of Glut1. Both proteins are elevated in breast cancer patient samples but have not yet been linked to diet-induced effects.
conclusionsUsing SAD2, we demonstrated that an American-style diet increased weight and adiposity while promoting the accumulation of oxidative DNA damage and AGEs and the expression of oncogenic Foxm1 within a relatively short diet interval. These data suggest that the SAD2 diet may offer insight into mechanisms that promote breast cancer aggressiveness and resistance to therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.