ArticleBMC oral health2025
Effect of intracanal medicaments on dentinal tubule penetration of root canal sealers: a confocal laser scanning microscopy study.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Influence of activation systems on the removal and apical extrusion of a bioceramic intracanal medicament in immature teeth: an in vitro study.European oral research · 2026Article
- Antibiotic approaches to endodontic regeneration.Biomaterial investigations in dentistry · 2026Review
- Impact of vehicle and insertion method on intratubular penetration of calcium hydroxide pastes: an in vitro confocal laser microscopy analysis.European oral research · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated the effect of three intracanal medicaments on the penetration ability of three different root canal sealers using confocal laser scanning microscopy (CLSM). MATERIALS AND
methods120 extracted single-rooted human teeth were used. The crowns were removed, and each canal was prepared. The teeth were divided into four groups (n = 30): three medicament groups (calcium hydroxide (CH), triple antibiotic paste (TAP), and double antibiotic paste [DAP]) and one control group. 0.1% Rhodamine B was incorporated. After three weeks, the medicaments were removed, and then canals were filled with one of the following sealers: AH Plus, MTA Fillapex, and TotalFill (n = 10). Fluorescein dye was added to the sealers. Horizontal sections (1 mm thick) were taken from each canal's coronal, middle, and apical portions. Samples were then viewed under CLSM. Statistical analysis was performed using Kruskal-Wallis and Mann-Whitney U tests.
resultsTotalFill exhibited the highest dentinal tubule penetration values across all root levels and medicament groups, followed by AH Plus and MTA Fillapex. However, these differences were not statistically significant (p > 0.05). All sealers showed greater penetration in the coronal third compared to the apical third.
conclusionsAlthough intracanal medicaments did not significantly affect sealer penetration, TotalFill demonstrated more consistent penetration patterns regardless of the medicament used.
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