ArticleBMC psychiatry2025
Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
objectiveThis study explored the changes in serum neurotrophic factor levels, the status of cognitive function, event-related potential P300, and the relationships between serum neurotrophic factor levels and cognitive functions, as well as event-related potential P300 in male schizophrenia patients with long-term hospitalization.
methodsA total of 82 male schizophrenia patients with long-term hospitalization and 52 healthy controls were recruited. Cognitive functions were evaluated in all participants, including verbal fluency function, attention function, executive function, and spatial function. Event-related potential P300 latency and amplitude were recorded using the Nicolet Viking Quest evoked potential system (USA). The serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) were measured in all participants using enzyme-linked immunosorbent assay (ELISA).
resultsThe patient group exhibited significantly poorer performance in all cognitive functions compared to the control group (p < 0.05). The patient group exhibited a statistically significant prolongation in P300 latency and a reduction in P300 amplitude compared to the control group (P < 0.01). In addition, serum BDNF levels were significantly lower in the patient group (9.1 ± 2.1 ng/ml) compared to the control group (11.6 ± 2.3 ng/ml, P < 0.01). Serum GDNF levels were 603.4 ± 182.6 pg/ml in the patient group and 610.2 ± 176.3 pg/ml in the control group, showing no statistically significant difference (P > 0.05). Onset levels were significantly correlated with almost all cognitive functions. BDNF levels were correlated to digital cancellation test scores (P < 0.05) and trail making test part B (TMT-part B) scores (P < 0.05). Moreover, a correlation was found between GDNF levels and block design test scores (P < 0.05). The latency of P300 was correlated to digital cancellation test scores (P < 0.01) and trail making test part A (TMT-part A) scores (P < 0.05). The amplitude of P300 was correlated with digital cancellation test scores (P < 0.01).
conclusionsThis study reveals that patients with chronic schizophrenia suffer from notable cognitive deficits during long-term hospitalization, which is linked to specific clinical characteristics. The patient group exhibited significantly lower serum BDNF levels than the control group. Event-related potential P300 testing revealed prolonged latency and reduced amplitude in patients. Serum BDNF and GDNF levels were selectively correlated with specific cognitive function performance.
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