ArticleBMC public health2025
Global burden and trends in ovarian cancer attributable to environmental risks and occupational risks in females aged 20-49 from 1990 to 2021, with projections to 2050: a cross-sectional study.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Multi-omics analysis identifieTranslational cancer research · 2026Article
- Spatiotemporal trends, demographic disparities, and predictions to 2040 in gastrointestinal cancer mortality in the United States.BMC public health · 2026Article
- Global Patterns and Temporal Trends in Ovarian and Uterine Cancer Mortality Attributable to High Body-Mass Index, 1990-2023.Cancers · 2026Article
- Global burden of ovarian cancer attributable to high BMI, 1990-2021: spatiotemporal trends, risk factors, frontier analysis, and projections to 2036 based on GBD 2021 study.Journal of ovarian research · 2025Article
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7 authors.
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Abstract
backgroundOvarian cancer is the eighth most common cancer globally, with environmental and occupational exposures emerging as critical determinants of ovarian carcinogenesis. Despite accumulating evidence, comprehensive global assessments of the burden of ovarian cancer attributable to these risks remain limited, especially among women aged 20-49 years.
methodsWe conducted a cross-sectional analysis using data from the Global Burden of Disease (GBD) Study 2021 to evaluate the global burden of ovarian cancer associated with environmental risks and occupational risks among females aged 20-49 years from 1990 to 2021. Outcomes included deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs). Temporal trends were analyzed using linear regression models, and future projections to 2050 were generated using autoregressive integrated moving average (ARIMA) and exponential smoothing (ES) models.
resultsIn 2021, ovarian cancer linked to environmental risks among females aged 20-49 years resulted in 38 deaths (95% uncertainty interval [UI]: 17-69) and 1786 DALYs (95% UI: 781-3233). The age-standardized DALYs rate (ASDAR) was 0.09 per 100,000 population (95% UI: 0.04-0.16). Similar results were observed for occupational risks. From 1990 to 2021, the number of cases and age-standardized rates (ASRs) for ovarian cancer linked to both environmental and occupational risks initially increased and then declined. Regionally, high-middle Sociodemographic Index (SDI) regions exhibited peak ASRs, while middle and low-middle SDI regions showed increasing trends. Projections from 2022 to 2050 indicated an upward trend in the number of cases using the ARIMA model, with decreasing trends for ASDR and ASYLLR.
conclusionOur study highlights the significant burden of ovarian cancer associated with environmental and occupational risks among women aged 20-49 years. The observed trends underscore the need for continued investment in prevention and control strategies, particularly in regions with high ASRs.
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