SynthesisBMC musculoskeletal disorders2025
Risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Risk factors and management of early pain non-response after vertebroplasty in osteoporotic vertebral compression fractures.Journal of spine surgery (Hong Kong) · 2026Article
- Role of Thoracolumbar Fascia Injury Classification in Predicting Percutaneous Vertebroplasty Outcomes for Osteoporotic Vertebral Compression Fractures.Journal of pain research · 2026Article
- Integrating core muscle morphology into a predictive model for residual back pain after vertebral augmentation.Frontiers in surgery · 2026Article
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5 authors.
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Abstract
backgroundResidual back pain (RBP) following vertebral augmentation negatively impacts clinical satisfaction and compromises both the physical and psychological well-being of affected patients. This meta-analysis aimed to identify risk factors associated with RBP after vertebral augmentation in patients with osteoporotic vertebral compression fractures (OVCF).
methodsWe searched literature in the PubMed, Embase, Web of Science and Cochrane Library. PRISMA guidelines were followed in this review. The Newcastle-Ottawa Scale (NOS) were used to evaluate the quality of included studies. Odds ratio (OR), mean difference (MD) and 95% confidence interval (CI) of potential risk factors were calculated via RevMan5.4.
resultsA total of 11 studies and 3290 patients were included in this meta-analysis. 12 risk factors were assessed and the outcome showed that lower BMD (MD = 0.39, 95% CI 0.27 ~ 0.52, p < 0.01), lower BMI (MD = -1.22, 95% CI -2.38 ~ -0.06, p = 0.04), depression (OR = 2.72, 95% CI 1.48 ~ 5.01, p < 0.01), adjacent vertebral fracture (OR = 2.53, 95% CI 1.42 ~ 4.50, p < 0.01), posterior fascia injury (OR = 3.94, 95% CI 3.10 ~ 5.00, p < 0.01), intravertebral vacuum cleft (OR = 2.33, 95% CI 1.56 ~ 3.50, p < 0.01), severe paraspinal muscle degeneration (OR = 6.25, 95% CI 4.09 ~ 9.53, p < 0.01), facet joint violation (OR = 7.71, 95% CI 3.50 ~ 17.00, p < 0.01), unsatisfied bone cement distribution (OR = 2.82, 95% CI 1.67 ~ 4.76, p < 0.01), less bone cement volume (MD = -0.24, 95% CI -0.45 ~ -0.03, p = 0.02), less recovery rate of anterior vertebral height (MD = -3.46, 95% CI -6.22 ~ -6.09, p = 0.01), less postoperative local kyphosis correction rate (MD = -4.74, 95% CI -6.43 ~ -3.06, p < 0.01) were associated with postoperative RBP in OVCF patients.
conclusionLower BMD, lower BMI, depression, adjacent vertebral fracture, posterior fascia injury, intravertebral vacuum cleft, severe paraspinal muscle degeneration, facet joint violation, unsatisfied bone cement distribution, less bone cement volume, less recovery rate of anterior vertebral height, and less postoperative local kyphosis correction rate were associated with an increased risk of RBP after vertebral augmentation in OVCF patients. Early identification and targeted management of high-risk patients may help reduce RBP incidence.
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