ArticleJACC. Case reports2025
Kratom-Associated Acute Right Ventricular Dysfunction: Diagnostic and Management Insights.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat.Pharmaceutical biology · 2025Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKratom (Mitragyna speciosa) is a psychoactive herbal supplement with stimulant and opioid-like properties, with emerging reports linking it to cardiovascular toxicity. However, its association with right ventricular (RV) function remains unclear. CASE SUMMARY: We report the case of a 52-year-old man who presented in shock with hypoxia and multiorgan dysfunction. Echocardiography revealed severe RV dilation with McConnell's sign, whereas chest computed tomography angiography ruled out pulmonary embolism. Right heart catheterization confirmed elevated right-sided pressures and high cardiac output consistent with high-output RV failure. DISCUSSION: Despite intermittent Kratom use, other etiologies, including thyrotoxicosis, arteriovenous fistula, liver disease, thiamine deficiency, and infection, were systematically excluded. With supportive management, including inotropic therapy, the patient's RV function recovered. TAKE-HOME MESSAGES: This case emphasizes the importance of recognizing Kratom as a potential factor in unexplained acute RV dysfunction. It highlights the value of prompt echocardiographic and hemodynamic assessment in guiding effective management.
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