ArticleJACC. Case reports2025
First-in-Human Experience of Targeted Coronary Sonothrombolysis: A Novel Approach for Management of Refractory Coronary Thrombus.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Acoustically driven micro/nanobubbles: from fundamental mechanisms to biomedical applications.Microsystems & nanoengineering · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntravenous sonothrombolysis is an emerging strategy for management of acute coronary syndromes. This involves intravenous administration of echocardiographic ultrasound enhancing agents with subsequent ultrasound-induced microbubble rupture using echocardiography. However, it is challenging to isolate a specific cardiac distribution. We sought to overcome this with targeted coronary sonothrombolysis. CASE SUMMARY: In a case of acute coronary syndrome with extensive thrombus burden, targeted coronary sonothrombolysis was performed with perflutren microbubbles injected directly into the thrombus and subsequently ruptured using echocardiography, leading to significant reduction in thrombus burden and normalization of coronary flow. DISCUSSION: Injection of perflutren microbubbles into the thrombus with subsequent opacification of only the myocardium supplied by the infarct-related artery is an effective means to deliver therapy to the appropriate location. TAKE-HOME MESSAGE: Targeted coronary sonothrombolysis helps overcome some of the difficulties observed with sonothrombolysis and may be a novel technique for management of coronary thrombus.
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Registered trials
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