Evidence map›Paper›PMID 40712829›Full record

ArticleBiomedical journal2026

Anisomeles indica enriched with ovatodiolide protects against aspirin-induced gastric ulcers through gut microbiota modulation.

Hsiu-Man Lien, Yu-Yen Wang, Shiao-Wen Li, Hwai-Jeng Lin, Hui-Yu Wu, Yu-Tsen Huang, Chun-Ya Chen, Chia-Chang Chen, Cheng-Hsun Chiu, Chih-Ho Lai

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Article in Biomedical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Odyssey of macrophages.Biomedical journal · 2026
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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Hsiu-Man LienDepartment of Food Science and Technology, Hungkuang University, Taichung, Taiwan.
Yu-Yen WangDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.
Shiao-Wen LiDepartment of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan.
Hwai-Jeng LinDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang-Ho Hospital, New Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Hui-Yu WuDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.
Yu-Tsen HuangDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.
Chun-Ya ChenDepartment of Laboratory Medicine, Taichung Veterans General Hospital Chiayi Branch, Chiayi, Taiwan.
Chia-Chang ChenYushen Biotechnology Co., Ltd., Taichung, Taiwan.
Cheng-Hsun ChiuDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Chih-Ho LaiDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan; Department of Nursing, Asia University, Taichung, Taiwan; Institute of Immunology and Translational Medicine, Center for the Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan. Electronic address: chlai@mail.cgu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric ulcers are commonly caused by improper use of aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), or Helicobacter pylori infection. Anisomeles indica (L.) Kuntze, a traditional herbal medicine enriched with ovatodiolide, possesses potent anti-bacterial and anti-inflammatory properties and has demonstrated efficacy in improving gastric ulcers in animal models. However, its impact on the gut microbial ecosystem remains unclear. This study aimed to evaluate the therapeutic effects of A. indica fractions enriched with ovatodiolide on aspirin-induced gastric ulcers and to investigate their influence on gut microbiota composition. MATERIALS AND

methodsAspirin-induced gastric ulcers were established in mice, followed by treatment with various A. indica fractions. The severity of gastric ulceration was assessed using histopathological analysis. Additionally, 16S rRNA V3-V4 sequencing and 16S amplicon library construction were performed to characterize gut microbiota composition.

resultsOur results showed that mice treated with ovatodiolide-enriched A. indica fractions exhibited significant amelioration of gastric ulcers compared to untreated controls. The treatment also enhanced the relative abundance of beneficial gut microbiota, including Lactobacillus and Adlercreutzia. Furthermore, histopathological examination revealed that A. indica treatment significantly upregulated mucin expression in ulcerated gastric tissues, suggesting a protective role in gastric mucosal integrity.

conclusionsThis study provides insights into the mechanisms by which A. indica alleviates gastric ulcers, highlighting its ability to modulate gut microbiota and enhance mucosal protection.

Indexed as

AspirinDiterpenesGastrointestinal MicrobiomeLamiaceaeStomach UlcerAnimalsAnti-Inflammatory Agents, Non-SteroidalMaleMicePlant ExtractsAnti-Inflammatory Agents, Non-SteroidalAspirinDiterpenesPlant ExtractsAnisomeles indicaMicrobiota compositionMucinNSAIDPeptic ulcer

Identifiers

PMID40712829
PMCPMC13084822

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.