Evidence map›Paper›PMID 40712746›Full record

Observational studyThe Journal of pediatrics2025

Bothersome and Impactful Health Conditions in Children and Adolescents with Down Syndrome.

Mary Witt, Michelle Palumbo, Stephanie L Santoro

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04631237 (Developing a Down Syndrome Health Instrument), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04631237 completednot on this map

Developing a Down Syndrome Health Instrument

TypeobservationalSponsorMassachusetts General HospitalRan2020 to 2025Enrolled758ConditionsDown Syndrome, Health, SubjectiveArmsObservational, no intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mary WittDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA.
Michelle PalumboDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Harvard Medical School, Boston, MA.
Stephanie L SantoroDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Harvard Medical School, Boston, MA. Electronic address: ssantoro3@mgh.harvard.edu.

Funding

Developing a Down Syndrome Health InstrumentK23HD100568 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SANTORO, STEPHANIE LYNN · 2020 to 2024
$847k
NICHD NIH HHS K23 HD100568
6 · The paper itself

Abstract

objectiveTo summarize our results regarding how physical and mental health affect or bother children and adolescents with Down syndrome (DS) and to explore the relationship between impactful or bothersome items and participants' overall health. STUDY

designWe surveyed caregivers of individuals aged 0-21 with DS about the aspects of physical health (including communication, hearing, vision, muscle tone, mobility, sleep, genitourinary concerns, and pain) and mental health (including behavior, self-talk, and problem solving) that bother and affect individuals with DS and summarized their responses. We compared the differences in sleep impacts between those with and without sleep apnea through chi square analysis. Spearman correlations were conducted to determine the association between our bother and impact items and total health scores on the DS health measure.

resultWe received 542 complete survey responses from a national sample. Physical and mental health impacted children and adolescents with DS at varied rates. Those with sleep apnea experienced negative impacts of sleep more frequently than those without. Thirty-four of our bother and impact items correlated significantly with total health scores.

conclusionsMany factors influenced some children and adolescents with DS, but most were not highly impactful. Although the bothersome and impactful aspects of physical and mental health were variable in our cohort, many correlated with overall health.

trial registrationClinicalTrials.gov: NCT04631237.

Indexed as

Down SyndromeHealth StatusMental HealthQuality of LifeAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleSurveys and QuestionnairesYoung AdultbotherDown syndromehealthimpactsurveytrisomy 21

Identifiers

PMID40712746
PMCPMC13284730

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.