Evidence map›Paper›PMID 40712578›Full record

ArticleDevelopmental cell2025

Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs.

Sergio Menchero, Christopher Barrington, Clare Critcher, Wazeer Varsally, Gregorio Alanis-Lobato, Kathy K Niakan, James M A Turner

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In one paragraph

Article in Developmental cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Sergio MencheroSex Chromosome Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK. Electronic address: sergio.menchero@crick.ac.uk.
Christopher BarringtonBioinformatics & Biostatistics, The Francis Crick Institute, London NW1 1AT, UK.
Clare CritcherSex Chromosome Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Wazeer VarsallySex Chromosome Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Gregorio Alanis-LobatoHuman Embryo and Stem Cell Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Kathy K NiakanHuman Embryo and Stem Cell Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Physiology, Development and Neuroscience, The Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EL, UK; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK.
James M A TurnerSex Chromosome Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK. Electronic address: james.turner@crick.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-cell transcriptomics has demonstrated conserved and divergent programs of organogenesis in mammals, but existing studies have focused on eutherians. Marsupials exhibit short gestation and complete development externally, necessitating accelerated differentiation of anterior features required for locomotion and feeding. Hence, they represent a unique outgroup for studying temporal shifts in development, known as heterochrony. Here, we generate a single-cell transcriptomic atlas of gastrulation and early organogenesis in a marsupial, the opossum Monodelphis domestica. We identify previously undocumented tissues undergoing heterochrony and find that transcriptional programs that form anterior structures initiate earlier and progress faster relative to eutherians. The result is uncoupling of transcriptional and morphological timelines, revealing unforeseen diversity in mammalian developmental sequences. Using our transcriptomic dataset, we identified translation as a candidate control mechanism by which anterior prioritization is achieved. Our findings provide insight into the asynchronous progression of developmental programs in marsupials.

Indexed as

Gene Expression Regulation, DevelopmentalMonodelphisOrganogenesisSingle-Cell AnalysisTranscriptomeAnimalsGastrulationMarsupialiacross-species comparisonsdevelopmental timingembryogenesisheterochronyopossumorganogenesissingle-cell RNA-seqtranslation

Identifiers

PMID40712578
PMCPMC7619616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.