Evidence map›Paper›PMID 40712114›Full record

ArticleJCO oncology practice2026

Impact of Drug Shortages on Cancer Care Delivery Within the National Cancer Institute Community Oncology Research Program.

Lauren V Ghazal, Supriya Mohile, Kah Poh Loh, Karen Mustian, Grace Sventek, Umang Gada, Chin-Shang Li, Eva Culakova, Melyssa Foust, Judith O Hopkins and 4 more

Abstract read
In one paragraph

Article in JCO oncology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lauren V GhazalUniversity of Rochester School of Nursing, Rochester, NY.ORCID 0000-0001-5768-5571
Supriya MohileDivision of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, URCC Research Base, Rochester, NY.
Kah Poh LohDivision of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0002-6978-0418
Karen MustianUniversity of Rochester School of Medicine & Dentistry, URCC Research Base, Rochester, NY.
Grace SventekDepartment of Public Health Sciences, University of Rochester School of Medicine & Dentistry, Rochester, NY.
Umang GadaUniversity of Rochester School of Medicine & Dentistry, Rochester, NY.
Chin-Shang LiUniversity of Rochester School of Medicine & Dentistry, Rochester, NY.
Eva CulakovaDepartment of Surgery, University of Rochester Medical Center, Rochester, NY.ORCID 0000-0002-9852-6515
Melyssa FoustGibbs Cancer Center & Research Institute, Upstate Carolina NCORP, Greer, SC.
Judith O HopkinsSCOR PI/Novant Health Cancer Institute, Kernersville, NC.ORCID 0000-0002-9829-1242
Heather KehnMetro-Minnesota Community Oncology Research Consortium, St Louis Park, MN.
Charles KamenUniversity of Rochester School of Medicine & Dentistry, URCC Research Base, Rochester, NY.ORCID 0000-0002-4219-4320
Erin R FoxUniversity of Utah Health, University of Utah College of Pharmacy, Salt Lake City, UT.ORCID 0000-0003-0070-0501
Elaine L HillDepartment of Public Health Sciences, University of Rochester School of Medicine & Dentistry, URCC Research Base, Rochester, NY.ORCID 0000-0003-2494-317X

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

purposeDrug shortages represent a challenge in oncology care, with potential repercussions including suboptimal treatment options, treatment delays, and medication errors. However, there is scant evidence on how drug shortages interrupt cancer care delivery (CCD) nationally and specifically across National Cancer Institute (NCI) Community Oncology Research Program (NCORP) community oncology practices.

methodsBetween December 2020 and July 2024, 96 NCORP community oncology practices were enrolled. NCORP practice study staff completed the Drug Shortage Baseline Survey and Pharmacy Baseline Survey. The primary outcome was proportion of practices seriously affected by drug shortages (ie, encountered CCD problems [change to less effective treatments, adoption of more toxic alternatives, treatment delays, or an increase in medication errors or near misses]) in the past 3 months. Secondary outcomes included CCD problems among practices (eg, ethical dilemmas) and strategies used by practices (eg, use of alternative drugs, stockpiling). Finally, we described differences between seriously affected and nonaffected practices.

resultsNearly 54% of NCORP practices were seriously affected by drug shortages in the past 3 months, with 23 drugs (including carboplatin [24.7%], leucovorin [22.6%], and cisplatin [19.4%]). Seriously affected practices were more likely to report lack of suitable alternatives (34.7%

conclusionDrug shortages influenced CCD among NCORP practices. This study underscores the need for robust strategies and policies to mitigate these effects and enhance the resilience of oncology practices.

Indexed as

Antineoplastic AgentsDelivery of Health CareMedical OncologyNeoplasmsHumansNational Cancer Institute (U.S.)United StatesAntineoplastic Agents

Identifiers

PMID40712114
PMCPMC12313152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.