ArticleJCO precision oncology2025
Genomic Landscape and Clinical Relevance in Chinese Patients With Upper Tract Urothelial Carcinoma.
Article in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- SPP1-driven spatial niche remodelling defines aggressive progression in the basal subtype of upper tract urothelial carcinoma.Clinical and translational medicine · 2026Article
- Immunohistochemistry-based risk stratification of upper tract urothelial carcinoma.Frontiers in oncology · 2026Article
- Exploratory analysis of the molecular and genomic landscape of upper tract urothelial carcinoma using long-read sequencing.BMC cancer · 2025Article
- Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis.BMJ oncology · 2024Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeUpper tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Although large cohorts have illustrated spectrum of germline mutations, landscape of somatic alterations has not been revealed in Chinese patients with UTUC.
methodsThis study involved 122 Chinese patients with UTUC. Paired tumor and germline DNA was sequenced to elucidate somatic mutation landscape, using targeted next-generation sequencing panel covering 520 cancer-related genes. We correlated specific gene mutations with clinicopathologic features, compared mutational signatures with previously reported data in other populations, and explored the similarities and differences in mutational signatures of UTUC originated from renal pelvis or ureter.
resultsSomatic mutations were detected in 120/122 (98.4%) patients using this 520-gene panel sequencing. The top-ranking altered genes in Chinese patients with UTUC were
conclusionThis study elucidated genomic landscape of Chinese patients with UTUC and revealed similarity and disparity of genomic alterations with other populations. Our research lays the foundation for understanding UTUC in China and designing precise diagnosis and treatment.
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