Evidence map›Paper›PMID 40712046›Full record

ArticleScience immunology2025

Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ-producing lymphocytes.

Nathan W Zammit, Ariana Vargas-Castillo, P Kent Langston, Gang Wang, Yangzhong Zhou, Bruce M Spiegelman, Christophe Benoist, Diane Mathis

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. GPSM1 restricts CD73Nature communications · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nathan W ZammitDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-3694-2951
Ariana Vargas-CastilloDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.ORCID 0000-0003-3239-6022
P Kent LangstonDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Gang WangDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4066-5280
Yangzhong ZhouDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Bruce M SpiegelmanDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1172-6555
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6110-4626

Funding

Adipose-tissue Tregs: important players in immunological control of metabolismR01DK092541 · NIDDK · HARVARD MEDICAL SCHOOL · PI DIANE J MATHIS · 2011 to 2026
$6.4M
P&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron S Leong · 2023 to 2026
$5.4M
Muscle regulatory T cells in exercise and agingF32AG072874 · NIA · HARVARD MEDICAL SCHOOL · PI LANGSTON, PAUL KENT · 2021 to 2023
$210k
NIA NIH HHS F32 AG072874NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK092541
6 · The paper itself

Abstract

Whereas visceral adipose tissue (VAT) primarily stores excess energy, brown adipose tissue (BAT) dissipates it in a process termed nonshivering thermogenesis. Several key VAT features, particularly murine epidydimal VAT, are regulated by a distinct population of regulatory T (T

Indexed as

Adipose Tissue, BrownInterferon-gammaThermogenesisT-Lymphocytes, RegulatoryAnimalsMaleMiceMice, Inbred C57BLInterferon-gamma

Identifiers

PMID40712046
PMCPMC12363373

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.