ArticleScience advances2025
The secreted protein PCYOX1L controls the surface expression of acid-sensing ion channel 1a.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Acid Sensing Ion Channels (ASICs) in the brain: emerging roles in physiology and pathology.Pflugers Archiv : European journal of physiology · 2026Review
- Acid-sensing ion channels in the vasculature: emerging roles in systemic and pulmonary circulations.Pflugers Archiv : European journal of physiology · 2026Review
- With a little help from a friend - a new partner for acid-sensitive channels.Pflugers Archiv : European journal of physiology · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modulation of neurotransmitter receptor density is an important molecular mechanism underlying synaptic plasticity. Acid-sensing ion channel 1a (ASIC1a), a receptor for protons, plays an important role in synaptic transmission. In this study, we used high-resolution proteomic analysis to identify prenylcysteine oxidase 1 like (PCYOX1L) as a hitherto unknown interaction partner of ASIC1a. We found that PCYOX1L is a secreted protein that promotes ASIC1a assembly. PCYOX1L was indispensable for ASIC1a expression in the plasma membrane and synaptosomes, and the genetic deletion of PCYOX1L severely impaired hippocampal long-term potentiation. Endocytosed PCYOX1L promoted plasma membrane expression of ASIC1a, and PCYOX1L secreted from astrocytes induced ASIC1a activity in neurons. Our findings reveal that a secreted protein, PCYOX1L, is a checkpoint for the plasma membrane expression of a synaptic ion channel.
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