Evidence map›Paper›PMID 40712021›Full record

ArticleScience advances2025

Defining the genetic determinants of CD8

Esther S Ng, Gusztav Milotay, Orion Tong, Chelsea A Taylor, Shawn Sun, Guangyi Niu, Robert Watson, Bo Sun, Sophie MacKay, James J Gilchrist and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Esther S NgKennedy Institute of Rheumatology, Oxford, UK.ORCID 0000-0003-2750-3452
Gusztav MilotayMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Orion TongMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-0659-5944
Chelsea A TaylorMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-1635-4167
Shawn SunMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Guangyi NiuMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Robert WatsonMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-8838-9406
Bo SunMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-5507-6657
Sophie MacKayMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-2882-1797
James J GilchristMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-2045-6788
Martin LittleMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-2592-1570
Benjamin P FairfaxMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-7413-5002
Yang LuoKennedy Institute of Rheumatology, Oxford, UK.ORCID 0000-0001-7385-6166

Funding

Wellcome Trust
6 · The paper itself

Abstract

The relationship between genetic variation and CD8

Indexed as

CD8-Positive T-LymphocytesImmune Checkpoint InhibitorsNeoplasmsReceptors, Antigen, T-CellHLA AntigensHumansHLA AntigensImmune Checkpoint InhibitorsReceptors, Antigen, T-Cell

Identifiers

PMID40712021
PMCPMC12292918

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.