Temporal Variability Analysis of Cortical Blood Flow in Rats with Hyperacute Cerebral Ischemia.

Bochao Niu, Benjamin Klugah-Brown, Yang Xia, Dezhong Yao, Bharat B Biswal

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Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Bochao NiuThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China.ORCID http://orcid.org/0009-0004-9712-732X

Benjamin Klugah-BrownThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China.ORCID http://orcid.org/0000-0002-3946-9557

Yang XiaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China.

Dezhong YaoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. dyao@uestc.edu.cn.ORCID http://orcid.org/0000-0003-0336-0522

Bharat B BiswalThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. bbiswal@gmail.com.ORCID http://orcid.org/0000-0002-3710-3500

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia restricts cerebral blood flow (CBF), leading to unstable hemodynamics. Past studies of ischemia mainly focused on cortical CBF reduction. However, its impact on hemodynamic changes, especially temporal varying characteristics, remains poorly understood. Here, we collected cortical resting-state CBF in rats with left carotid artery blockage during occlusion-reperfusion, and measured the temporal variability and changes in laterality using a novel state-space method. This method was also applied to stroke EEG datasets to validate its effectiveness. After arterial occlusion, the left marginal motor, sensory, auditory, and visual cortices exhibited severe temporal variability impairments. The laterality analysis indicated that affected left regions showed inferior unilateral mean, inter-hemispheric transition probability, time fraction, and laterality duration, while the right side had a higher laterality time fraction and duration. These impairments recovered partially following blood flow restoration. Besides, the ischemic state-space metrics were positively correlated with the pre-occlusion baseline appearance. Stroke patients exhibited impaired temporal variability in the affected ischemic hemisphere. The state-space analysis revealed damaged CBF temporal variability during cerebral ischemia and predicted baseline-ischemia connections.

Indexed as

Brain IschemiaCerebral CortexCerebrovascular CirculationAnimalsDisease Models, AnimalElectroencephalographyFunctional LateralityHumansMaleRatsRats, Sprague-DawleyCerebral blood flowCerebral ischemiaLaser speckle contrast imagingState-spaceTemporal variability

Identifiers

PMID40711751

DOI10.1016/j.resuscitation.2017.07.020

PMCPMC12789369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.