ArticleDigestive diseases and sciences2025
Intratumoral Microbe Correlated with Expression of DNA Methylation Genes in Hepatocellular Carcinoma.
Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Tumor-resident microorganisms as clinical biomarkers in primary liver cancer: A systematic review of current evidence.World journal of gastrointestinal oncology · 2025Article
- Integrated Proteomics Reveal ALDH1A1 as an Oncogenic Driver and Regulatory Hub in Hepatocellular Carcinoma.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntratumor microbiota are increasingly implicated in cancer pathogenesis, with emerging evidence suggesting their role in regulating DNA methylation pathways in hepatocellular carcinoma (HCC). This study investigates the interactions between specific bacterial genera and key DNA methylation-related genes in HCC tissues.
methodsTumor and adjacent normal tissues from 72 HCC surgical patients were analyzed. Bacterial composition was characterized via 16SrRNA sequencing, while quantitative analysis assessed the abundance of differential bacterial genera and expression of DNA methylation pathway genes linked to HCC outcomes.
resultsSix bacterial genera exhibited differential abundance between tumor and normal tissues: Propionibacterium, Mycoplasma, Variovorax, OPB41, unclassified_Bifidobacteriaceae, and Rikenellaceae. Key gene-microbiota correlations included: Negative associations of Propionibacterium with SPOCD1 and EOMES; Negative associations of Mycoplasma with BMI1 and EZH2; Negative correlations of Pseudomonas with BMI1, EOMES, EZH2, and SPOCD1. Additionally, Pseudomonas abundance was negatively correlated with both Propionibacterium and Mycoplasma.
conclusionThe identified microbiota-gene interactions reveal potential mechanistic links between intratumor flora and HCC progression via DNA methylation regulation. These findings highlight novel targets for further exploration of HCC therapeutic strategies.
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