ArticleCell biochemistry and biophysics2025
Immunomodulatory Activity of Propafenone Hydrochloride on Mammalian Macrophages in the Presence of LPS.
Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nortriptyline exerts context-dependent cytokine modulation and reduces pHrodo-associated phagocytic response in activated J774.2 macrophages.Molecular biology reports · 2026Article
- The investigation of immunomodulatory effects of didemnin B in macrophage cells.Immunologic research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propafenone is an antiarrhythmic medication with the properties that span both class 1 and class 2 antiarrhythmic drugs. It regulates the heart rhythm through the blockage of sodium channel, potassium channel, and beta receptors. In the literature, there are studies related to the effects of Propafenone on atrial fibrillation, as well as its potential anti-cancer and anti-epileptic effects. However, there is currently insufficient research on Propafenone's immunomodulatory effects. In this study, the immunomodulatory activity of propafenone was tested. Impact of Propafenone on TNF-α, IL-6, Il-12p40 and GM-CSF cytokines production by J774.2 macrophage cell line was evaluated in the presence and absence of LPS (lipopolysaccharide). Cytokine production level was tested in the presence of propafenone. The results showed that Propafenone alone did not significantly stimulate cytokine release, but in the presence of LPS, it showed a significant effect and demonstrated anti-inflammatory activity. Propafenone has anti-inflammatory activity. At the clinical setting this information should be taken into the consideration if anti-inflammatory drug utilization is also necessary to prevent extra usage of the drug molecules. In case of infections, the patients who are using propafenone should get immune boosting supplements to be able to cope with the infectious agent.
Indexed as
Identifiers
40711730What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.